The role of heat shock protein 90 in regulating pain, opioid signaling, and opioid antinociception.

The role of heat shock protein 90 in regulating pain, opioid signaling, and opioid antinociception. Vitam Horm. 2019;111:91-103 Authors: Streicher JM Abstract Heat shock protein 90 (Hsp90) is one of the central signal transduction regulators of the cell. Via client interactions with hundreds of proteins, including receptors, receptor regulatory kinases, and downstream signaling regulators, Hsp90 has a crucial and wide-ranging impact on signaling in response to numerous drugs with impacts on resultant physiology and behavior. Despite this importance, however, Hsp90 has barely been studied in the context of pain and the opioid receptor system, leaving open the possibility that Hsp90 could be manipulated to improve pain therapeutic outcomes, a current area of massive medical need. In this review, we will highlight the known roles of Hsp90 in directly regulating the initiation and maintenance of the pain state. We will also explore how Hsp90 regulates signaling and antinociceptive responses to opioid analgesic drugs, with a special emphasis on ERK MAPK signaling. Understanding this new and growing area will improve our understanding of how Hsp90 regulates signaling and physiology, and also may provide new ways to treat pain, and perhaps reduce the severe impact of the ongoing opioid addiction and overdose crisis. PMID: 31421708 [PubMed - in process]
Source: Vitamins and Hormones - Category: Endocrinology Authors: Tags: Vitam Horm Source Type: research

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While Suboxone can be a helpful tool for many, it is important to also understand its addictive nature. Because it is an opioid, wondering if you can form an addiction to Suboxone can be answered simply: Yes. Although the rates of addiction are much smaller than those of other opioids, it is still important to take their addictive properties seriously and get help if you start to notice the signs and symptoms of addiction to Suboxone. What is Suboxone? According to their own website, Suboxone is a prescription medicine that contains the active ingredients buprenorphine and naloxone. It is used to treat adults who are depe...
Source: Cliffside Malibu - Category: Addiction Authors: Tags: Addiction Addiction to Pharmaceuticals Substance Abuse addiction treatment addictionologist detox drug detox medical detox medicated-assisted detox prescription drug detox prescription medication suboxone Source Type: blogs
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Source: Pain Management Nursing - Category: Nursing Authors: Tags: Review Article Source Type: research
An Oklahoma judge ordered Johnson &Johnson to pay $572 million for its role in the opioid crisis in a historic ruling on Monday, marking the first time an opioid manufacturer has been deemed responsible in court and made to pay damages. It could have implications for the slew of lawsuits filed against opioid manufacturers and distributors throughout the country. A much bigger federal case before an Ohio judge involves at least 1,600 consolidated lawsuits from cities and counties from across the country, including hard-hit regions like Portsmouth, Ohio and Huntington, W.Va. The nationwide suit was filed in Ohio because ...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized legal onetime opioids Source Type: news
Abstract The current opioid crisis has raised awareness of the risks of misuse, addiction, and overdose with opioid prescribing for pain management in the perioperative and nonoperative care of surgical patients. Despite these risks, it is essential for surgical providers to provide safe and adequate functional pain control to enhance recovery. The purpose of this review is to outline the relevance of the US opioid crisis to surgical prescribing, describe strategies for opioid reduction using a stepwise therapy approach, and provide recommendations for improving the safety of opioid prescribing. Additional recomme...
Source: The Medical Clinics of North America - Category: General Medicine Authors: Tags: Surg Clin North Am Source Type: research
On August 26 Oklahoma State Judge Thad Balkman  ruled that Johnson&Johnson must pay $572 million to the state of Oklahoma for contributing to the local opioid addiction crisis. Johnson&Johnson sold two opioids: a fentanyl skin patch with the brand name  Duragesic,  and  Nucynta,a synthetic opioid similar to tramadol but stronger.Nucynta is not as addictive as most other synthetic and semi-synthetic opioids and has been shown to have low levels of abuse in post-marketing studies. Fentanyl skin patches are very difficult and inconvenient to convert for non-medical use. The...
Source: Cato-at-liberty - Category: American Health Authors: Source Type: blogs
The U.S. Centers for Disease Control and Prevention is investigating a growing number of “severe” lung disease cases that appear to be related to vaping. Since late June, according to the CDC, 94 people in 14 states have come down with serious lung illnesses that may be linked to use of e-cigarettes, which heat substances including nicotine and cannabis to create aerosols that users inhale. The case count has grown high enough to prompt the CDC to work with state health departments to learn more about what could be causing the worrisome conditions, which are primarily affecting adolescents. Although “mor...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized onetime public health Source Type: news
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Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized onetime public health Source Type: news
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Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized onetime public health Source Type: news
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Source: Cato-at-liberty - Category: American Health Authors: Source Type: blogs
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Source: International Immunopharmacology - Category: Allergy & Immunology Authors: Tags: Int Immunopharmacol Source Type: research
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