Medical News Today: Dementia risk: The role of 'blood pressure patterns'

A new study investigates the importance of fluctuations in blood pressure from mid-age to later life. It asks how these changes relate to dementia risk.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Hypertension Source Type: news

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AbstractDyslipidaemia, metabolic syndrome, diabetes mellitus and arterial hypertension contribute to the risk of cognitive disorder and dementia. However very few and conflicting results are available with respect to the impact of lipoprotein ratios on cognitive functions in healthy individuals. Therefore, this study was aimed to investigate the association of lipid profile and its ratios with reaction time in young healthy individuals. 89 individuals (54 male and 35 female) with mean age of 31.20  ± 3.19 years were selected for this observational study conducted at AIIMS Rishikesh and written con...
Source: Indian Journal of Clinical Biochemistry - Category: Biochemistry Source Type: research
ConclusionsAdjustment of the cfPWV value may be necessary for a more accurate distinction between lower and higher risk group of patients for white matter microstructural injury related to arterial stiffness. Targeting the highest risk group for prevention methods may, in turn, help preserve brain health and cognitive functions.
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
ConclusionThis study highlights the high prevalence of unidentified or poorly controlled VRF in people with mild cognitive symptoms attending a memory service. Given its importance to brain health and mitigation of future cognitive decline, a structured focus on identifying and managing these VRF in this setting is necessary. Exercise-based lifestyle programs should be embedded in post-diagnostic services for this population.
Source: Age and Ageing - Category: Geriatrics Source Type: research
In this study, researchers studied 438,952 participants in the UK Biobank, who had a total of 24,980 major coronary events - defined as the first occurrence of non-fatal heart attack, ischaemic stroke, or death due to coronary heart disease. They used an approach called Mendelian randomisation, which uses naturally occurring genetic differences to randomly divide the participants into groups, mimicking the effects of running a clinical trial. People with genes associated with lower blood pressure, lower LDL cholesterol, and a combination of both were put into different groups, and compared against those without thes...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Consider performing a sleep study in patients with resistant hypertension as research shows strong link with OSA Related items fromOnMedica Could supplemental oxygen help sleep apnoea patients? NHS provision of sleep services fails to meet need CPAP helps control BP in apnoea patients Sleep disorder linked to brain changes indicative of dementia Researchers say a sense of purpose aids sleep
Source: OnMedica Latest News - Category: UK Health Source Type: news
U.K. researchers have developed a unique diffusion-tensor MR imaging algorithm...Read more on AuntMinnie.comRelated Reading: DTI-MRI offers window into Alzheimer's risk MRI links lifestyle factors to stroke, dementia risk MRI ties high blood pressure to dementia risk DTI-MRI ties lack of fitness to cognitive decline MRI shows possible link between blood flow, Alzheimer's
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Publication date: Available online 10 September 2019Source: SteroidsAuthor(s): Matthias Barton, Matthias R. Meyer, Eric R. ProssnitzAbstractChronic non-communicable diseases share the pathomechanism of increased reactive oxygen species (ROS) production by nicotinamide adenine dinucleotide phosphate (NADPH) oxidases, known as Nox. The recent discovery that expression of Nox1, a Nox isoform that has been implicated in the pathogenesis of cardiovascular and kidney disease, is regulated by the expression and activity of G protein-coupled estrogen receptor (GPER) led to the identification of orally active small-molecule GPER bl...
Source: Steroids - Category: Drugs & Pharmacology Source Type: research
We examined human lung tissue from COPD patients and normal control subjects, and found a substantial increase in p16-expressing alveolar cells in COPD patients. Using a transgenic mouse deficient for p16, we demonstrated that lungs of mice lacking p16 were structurally and functionally resistant to CS-induced emphysema due to activation of IGF1/Akt regenerative and protective signaling. Fat Tissue Surrounds Skeletal Muscle to Accelerate Atrophy in Aging and Obesity https://www.fightaging.org/archives/2019/09/fat-tissue-surrounds-skeletal-muscle-to-accelerate-atrophy-in-aging-and-obesity/ Researchers her...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
In conclusion, in the absence of obesity, visceral adipose tissue possesses a pronounced anti-inflammatory phenotype during aging which is further enhanced by exercise. Methods of Inducing Cellular Damage are Rarely Relevant to Aging, and the Details Matter https://www.fightaging.org/archives/2019/08/methods-of-inducing-cellular-damage-are-rarely-relevant-to-aging-and-the-details-matter/ One of the major challenges in aging research is determining whether or not models of cellular or organismal damage and its consequences are in any way relevant to the natural processes of aging. One can hit a brick with...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
CONCLUSIONS: Multiple antihypertensive use is associated with an increased risk of mortality in residents with diagnosed hypertension, particularly in residents with dementia and among those who are most frail. PMID: 31473981 [PubMed - as supplied by publisher]
Source: Aging Clinical and Experimental Research - Category: Geriatrics Authors: Tags: Aging Clin Exp Res Source Type: research
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