Prospects for Diminishing the Impact of Nonamyloid Small-Vessel Diseases of the Brain.

Prospects for Diminishing the Impact of Nonamyloid Small-Vessel Diseases of the Brain. Annu Rev Pharmacol Toxicol. 2019 Aug 19;: Authors: Joutel A Abstract Small-vessel diseases (SVDs) of the brain are involved in about one-fourth of ischemic strokes and a vast majority of intracerebral hemorrhages and are responsible for nearly half of dementia cases in the elderly. SVDs are a heavy burden for society, a burden that is expected to increase further in the absence of significant therapeutic advances, given the aging population. Here, we provide a critical appraisal of currently available therapeutic approaches for nonamyloid sporadic SVDs that are largely based on targeting modifiable risk factors. We review what is known about the pathogenic mechanisms of vascular risk factor-related SVDs and cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), the most frequent hereditary SVD, and elaborate on two mechanism-based therapeutic approaches worth exploring in sporadic SVD and CADASIL. We conclude by discussing opportunities and challenges that need to be tackled if efforts to achieve significant therapeutic advances for these diseases are to be successful. Expected final online publication date for the Annual Review of Pharmacology and Toxicology, Volume 60 is January 6, 2020. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates. PMID: 31425001 [PubMed - as supplied by publi...
Source: Annual Review of Pharmacology and Toxicology - Category: Drugs & Pharmacology Authors: Tags: Annu Rev Pharmacol Toxicol Source Type: research

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Mediterranean diet: The role of long-chain ω-3 fatty acids in fish; polyphenols in fruits, vegetables, cereals, coffee, tea, cacao and wine; probiotics and vitamins in prevention of stroke, age-related cognitive decline, and Alzheimer disease. Rev Neurol (Paris). 2019 Sep 11;: Authors: Román GC, Jackson RE, Gadhia R, Román AN, Reis J Abstract The mechanisms of action of the dietary components of the Mediterranean diet are reviewed in prevention of cardiovascular disease, stroke, age-associated cognitive decline and Alzheimer disease. A companion article provides a comprehensive revi...
Source: Revue Neurologique - Category: Neurology Tags: Rev Neurol (Paris) Source Type: research
ConclusionThe ICT service has augmented the existing Day Hospital with timely multi-disciplinary assessment and treatment enabling older persons ’ independence within their home in addition to forward planning if dependency levels increase. Additional benefits include reduction of primary care team waiting lists and forging links with our community and local rehab services. Future ambitions include recruitment of specialist nursing and dir ect referral pathways from our community colleagues.
Source: Age and Ageing - Category: Geriatrics Source Type: research
ConclusionThis case highlights the importance of genetics shaping phenotypes and that consideration should always be given to a full relevant family history.  It also shows a rare case of rapidly progressive dementia confirmed due to CJD with a likely underlying familial predisposition.
Source: Age and Ageing - Category: Geriatrics Source Type: research
ConclusionControls need to be brought in to ensure that PM2.5 does not exceed a 50μg/m3 level due to the increase in disease incidence associated with same. The urban burning of solid fuels should be severely restricted.
Source: Age and Ageing - Category: Geriatrics Source Type: research
ConclusionThis study highlights the high prevalence of unidentified or poorly controlled VRF in people with mild cognitive symptoms attending a memory service. Given its importance to brain health and mitigation of future cognitive decline, a structured focus on identifying and managing these VRF in this setting is necessary. Exercise-based lifestyle programs should be embedded in post-diagnostic services for this population.
Source: Age and Ageing - Category: Geriatrics Source Type: research
ConclusionThis study replicates Pendlebury and Rothwell ’s findings that over a third of people suffering from severe strokes will develop cognitive impairment. This is of critical importance to stroke clinicians as it should prompt frank discussions with stroke patients and their families about prognosis, recovery and future planning.
Source: Age and Ageing - Category: Geriatrics Source Type: research
In this study, researchers studied 438,952 participants in the UK Biobank, who had a total of 24,980 major coronary events - defined as the first occurrence of non-fatal heart attack, ischaemic stroke, or death due to coronary heart disease. They used an approach called Mendelian randomisation, which uses naturally occurring genetic differences to randomly divide the participants into groups, mimicking the effects of running a clinical trial. People with genes associated with lower blood pressure, lower LDL cholesterol, and a combination of both were put into different groups, and compared against those without thes...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Globally, Alzheimer’s disease and other forms of dementia are a major burden on individuals and communities. To make matters worse, there are few treatments to combat these complex illnesses. Even the causes of dementia are widely debated. Sadly, clinical trials for drugs to stop or even slow its progress have come up short. Taking a different tack, some experts hope to intervene before people are diagnosed with dementia by encouraging lifestyle changes. What is dementia and what makes it so complex? Dementia describes groups of specific diseases characterized by symptoms such as memory loss. The most common type of ...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Brain and cognitive health Genes Medical Research Memory Source Type: blogs
U.K. researchers have developed a unique diffusion-tensor MR imaging algorithm...Read more on AuntMinnie.comRelated Reading: DTI-MRI offers window into Alzheimer's risk MRI links lifestyle factors to stroke, dementia risk MRI ties high blood pressure to dementia risk DTI-MRI ties lack of fitness to cognitive decline MRI shows possible link between blood flow, Alzheimer's
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
A new MRI method may detect clues in stroke patients that can lead to future cognitive problems, as new findings show it predicted three-fourths of dementia cases in patients who had suffered strokes.
Source: Health News - UPI.com - Category: Consumer Health News Source Type: news
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