MicroRNA-204 inhibits the proliferation and metastasis of breast cancer cells by targeting PI3K/AKT pathway.
CONCLUSION: We conclude that miR-204 regulates the proliferation and metastasis of the breast cancer cells and as such may prove to be an important therapeutic target. PMID: 31424660 [PubMed - in process]
This article describes the comprehensive overview of the current scenario of drug repurposing for the breast cancer treatment. The strategies as well as several examples of repurposed drugs are provided. The challenges associated with drug repurposing are discussed.
1. The breast is the most heavily guarded and protected part of a woman ’s body. This means there is good reason to worry less. Did you know that a mammogram is one of only two imaging tests (the other being a low-dose lung cancer screening for former or current heavy smokers) paid for by insurance companies in the U.S. for asymptomatic patients without any risk facto rs? It is the only part of a woman’s body which gets scrutinized every year. Finding breast cancer early (stage 1: less than…
Authors: Han LC, Wang H, Niu FL, Yan JY, Cai HF Abstract OBJECTIVE: Studies showed that microRNAs (miRs) play an important role in the development of breast cancer. It has been shown that there were significant differences between the expression levels of serum miR-214-3p in breast cancer patients and healthy controls. Since survivin is involved in cell cycle and apoptosis, this study aims to investigate the effect of miR-214-3p on the proliferation and apoptosis of breast cancer cells. MATERIALS AND METHODS: Dual-Luciferase reporter system was used to validate the cell cycle-related target gene survivin. miRan...
CONCLUSIONS: LINC00511 inhibition impairs its competitive binding to miR-185, resulting in increased STXBP4 expression and improved radiation response in breast cancer. Our study results suggest that the LINC00511/miR-185/STXBP4 axis may be a promising therapeutic target for improving the prognosis of breast cancer. PMID: 31539133 [PubMed - in process]
CONCLUSIONS: Knockdown of LINC01096 inhibited cell viability, migration, and invasion; however, it promoted apoptosis in TNBC by up-regulating miR-3130-3p, indicating a novel target for the treatment of TNBC. PMID: 31539132 [PubMed - in process]
In this study, hyaluronic acid (HA)-mediated tumor targeting and pH-sensitive amphiphilic polymeric nanoparticles were designed and prepared to co-deliver the anticancer drug embelin (EMB) and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) plasmid (pTRAIL) (EMB/TRAIL-HA/PBAE-PEI) for synergistic anti-breast cancer efficacy. These pH-sensitive amphiphilic polymeric nanoparticles were formed using the amphiphilic polymers polyethyleneimine (PEI)-poly[(1,6-hexanediol)-diacrylate-β-5-hydroxyamylamine] (PBAE), which was synthesized via Michael addition polymerization. Taking advantage of the specific bindi...
In this study, we highlighted mechanisms underlying the regulation of breast cancer molecular signatures by TFs and miRNAs which their alteration reduce the chance of survival rate in each subtype of breast cancer. Our current study in a holistic insight revealed the importance of some genes and their regulators as potential prognostic markers and/or therapeutic targets in breast cancer patients.
This article outlines the most commonly used breast cancer prognostic tests, including the individual assay's purpose, its genomic makeup, the targeted patient population, and its prognostic and predictive abilities. Key nursing implications are discussed, highlighting how nurses can best apply knowledge of breast cancer prognostic tests to nursing practice. PMID: 31538973 [PubMed - in process]
This article describes the impact of a train-the-trainer program, with mission groups traveling to the Philippines to promote female residents' breast cancer awareness, knowledge, and intent for future screening. PMID: 31538970 [PubMed - in process]