Is Adjuvant Chemotherapy Worthwhile After Radical Resection for Single Lung Metastasis From Colorectal Cancer? A Multicentric Analysis Evaluating the Risk of Recurrence

Background. Adjuvant chemotherapy after resection of colorectal cancer (CRC) lung metastases may reduce recurrences and improve survival. The choice of best candidates for adjuvant chemotherapy in this setting is controversial, especially when a single lung metastases is resected. The aim of this study is to evaluate the risk of recurrence after radical resection for single lung metastasis from colorectal cancer (CRC). Patients and methods. Demographic, clinical and pathological data were retrospectively collected for patients radically operated for single pulmonary metastasis from CRC in 4 centers. Survival was computed by Kaplan-Meyer methods. Chi-square, log-rank test and, for multivariate analysis, Cox-regression and binary logistic regression were used when indicated. Results. The sample consisted of 344 patients, mean age 65-yrs. Overall 5-yrs survival was 61.9% respectively. Recurrence occurred in 113 pts (32,8%). At univariate analysis, age>70 (p=0.046) and tumour size>2 cm (p=0.038) were predictive of worst survival, while synchronous lung metastasis (p=0.039), previous resection of extrathoracic metastasis (p=0.017), uptake at FDG-PET scan (p=0.006) and short (4 ng/mL) was associated to worst survival (HR: 4.3, p=0.014), while prior abdominal surgery (HR: 3, p=0.033), PET positivity (HR: 2.7, p=0.041) and DFI> 12 months (HR: 0.14, p
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research