The next big LEAP2 understanding ghrelin function
Ghrelin is a key signal driving energy seeking and storage in order to reverse energy deficit. In line with this view, the metabolic status of an organism predicts sensitivity to ghrelin, with fasting increasing and obesity decreasing ghrelin sensitivity, respectively. However, the mechanism responsible for controlling this sensitivity is unknown. In this issue of the JCI, Mani and colleagues show that plasma levels of plasma liver-enriched antimicrobial peptide-2 (LEAP2), a recently identified hormone that antagonizes the ghrelin receptor, are inversely correlated with those of plasma acyl-ghrelin under conditions of both energy deficit and energy surplus in mice and humans. Their results show that a fall in plasma LEAP2 during energy deficit facilitates the actions of acyl-ghrelin, whereas increased LEAP2 in obesity suppresses the actions of acyl-ghrelin. This important discovery helps reshape our understanding of ghrelin function and may provide a new approach to aiding weight maintenance after diet-induced weight loss.
Conclusion Our study provides novel evidence that EXE-induced antisenescence against metabolic distress in the hippocampus may be a key neuroprotective mechanism, preventing neuroinflammation and oxidative stress.
Purpose Low-attenuation muscle (LAM) area at mid-thigh, a computed tomography (CT)–derived index of intramuscular lipids, is associated with insulin resistance, obesity, and type 2 diabetes. The present study aimed at testing the hypothesis that changes in LAM area in trunk muscles from a single abdominal scan could provide relevant information to evaluate the effects of a lifestyle intervention without the use of a mid-thigh CT scan. Methods Cardiometabolic risk variables, including waist circumference, lipoprotein–lipid profile, glucose tolerance, and cardiorespiratory fitness, were assessed in a sample ...
CONCLUSIONS: More than half of middle-aged women without cardiovascular symptoms present alterations in one or more exercise testing parameters. Alterations in the functional capacity or heart rate behavior, as verified by exercise testing, are associated with age, smoking, an overweight status and obesity.
Conclusions: the prevalence found was higher than that of other national researches, especially for the female gender. In the male gender, not having internet access, a lesser number of family members and a longer screen time proved to be factors associated with being excess weight.Resumo Objetivos: investigar a preval ência de excesso de peso e fatores associados entre adolescentes de uma comunidade de baixa renda situada na cidade do Recife, Pernambuco. Métodos: estudo transversal, em que foram coletadas informações demográficas, socioeconômicas e comportamentais no período ...
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Conclusion: The present study indicates a downward secular trend in the menarcheal age of the Saudi population. Moreover, a negative correlation between BMI and menarcheal age was also documented. PMID: 31522226 [PubMed - in process]
Publication date: Available online 16 September 2019Source: The American Journal of SurgeryAuthor(s): Minyoung Kwak, J. Hunter Mehaffey, Robert B. Hawkins, Angel Hsu, Bruce Schirmer, Peter T. HallowellAbstractIntroductionObesity is a risk factor for non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC). Bariatric surgery can provide durable weight-loss, but little is known about the later development of NASH and HCC after surgery.MethodsBariatric surgery (n=3,410) and obese controls (n=46,873) from an institutional data repository were propensity score matched 1:1 by demographics, comorbidities, BMI, and ...
Researchers from Boston, Massachusetts, found children who had a big difference between their weekday and weekend sleep schedules were the ones most likely to be obese.
Conditions: Obesity; Morbid Obesity; Diabetes Mellitus, Type 2; Atrial Fibrillation Intervention: Behavioral: Intermittent Fasting Sponsor: University of Chicago Recruiting
Condition: Obesity Interventions: Behavioral: Project Health; Other: Educational Video Control Sponsor: University of Houston Not yet recruiting