Warming Up to Oxazole: Noncryogenic Oxazole Metalation and Negishi Coupling Development

This report details the development of several suitable noncryogenic metalation conditions for the synthesis of oxazole zincate. Subsequent rounds of high-throughput catalyst screening ultimately led to the identification of several suitable Pd sources that can be used for the Negishi coupling of unsubstituted oxazole. The scope and generality for one of the reported conditions is also presented. [...] © Georg Thieme Verlag Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text

Source: Synlett - August 18, 2019 Category: Chemistry Authors: Geier, Michael J. Wang, Xiaotian Humphreys, Luke D. Calimsiz, Selcuk Scott, Mark E. Tags: letter Source Type: research