Necrotizing Enterocolitis: State of the Art in Translating Experimental Research to the Bedside
Eur J Pediatr Surg DOI: 10.1055/s-0039-1693994Necrotizing enterocolitis (NEC) is a devastating intestinal disease that continues to have high morbidity and mortality among preterm neonates, despite medical advancements in neonatology and neonatal care. To investigate the pathogenesis of the disease and explore novel form of treatment, a variety of experimental models of NEC have been developed and used by various investigators. These experimental models range from in vitro evaluation of intestinal epithelial cells and intestinal organoids to in vivo models of the disease in neonatal mice, rats, and piglets. Most recently, human-derived intestinal organoids have also been developed and investigated. In this review, we will briefly discuss these experimental models and the contributions that they have made to our understanding of NEC. We will also point to the ischemia/reperfusion (I/R) model of intestinal injury which has been used as an indirect model of NEC by some investigators. Advancements in laboratory research into this devastating disease have continued to expand our knowledge on the pathogenesis and prevention of NEC as well as the effectiveness of therapeutic options for management of this severe disease. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text
Date: Friday, 12 13, 2019; Speaker: various; Building 38; 2nd floor conference room B
Date: Tuesday, 12 17, 2019; Speaker: Dr. Erin Beck, NINDS; Dr. Kenneth Tyler, University of Colorado School of Medicine; Building: Building 10 (Clinical Center); Lipsett Auditorium; CME Credit
Date: Tuesday, 01 07, 2020; Speaker: Daniel Neafsey, Assistant Professor, Harvard T.H. Chan School of Public Health; 5625 Fishers Lane; 5th Floor Conference Room
The holidays are often thought of as a joyful time of the year, filled with sights and sounds of seasonal cheer. Yet for people struggling with the death of a family member or loved one, the holidays can be difficult.
Enter a keyword below to find answers to your AARP Research questions. ... About three in five older workers (61%) have either seen or experienced age discrimination in the workplace. ... You are l...
The editors and staff of the Annals of Allergy, Asthma and Immunology would like to thank the flowing individuals who gave of their time to provide reviews of submitted manuscripts between January 1 and June 30, 2019. The high-quality manuscript reviews provided by these individuals is essentially to the peer review process so necessary for a journal like ours to provide scientifically sound as well as interesting and engaging articles for our readers. Thanks to each of you for your service.