The Genetics of Human Longevity in a Nutshell: Only a Few Identified Variants, and Everything Else a Mystery

The human genetics of longevity are exceedingly complex, that much is possible to say from the research to date. Nearly every study of associations between gene variants and longevity in a human population identifies some correlations, and, barring just a few genes, none of those associations are found in any other study. So the genetics of longevity involves myriad tiny conditional contributions, each such contribution very dependent on a web of environmental factors and a network of other gene variants. This is one of the reasons why I see efforts to map the genetics of centenarians and long-lived families to be of only scientific interest. Given what we know of the genetics of longevity, research programs of that nature are very unlikely to deliver the basis for therapies that can make any meaningful difference to the pace of aging. Human average life expectancy in developed countries has increased dramatically in the last century, a phenomenon which is potentially accompanied by a significant rise in multi-morbidity and frailty among older individuals. Nevertheless, some individuals appear someway resistant to causes of death, such as cancer and heart disease, compared with the rest of the population, and are able to reach very old ages in good clinical conditions, while others are not. Thus, during the last two decades we have witnessed an increase in the number of studies on biological and molecular factors associated with the variation in healthy aging and lon...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs

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By Sandee LaMotte, CNN (CNN) — If certain vegetables have always made you gag, you may be more than a picky eater. Instead, you might be what scientists call a “super-taster:” a person with a genetic predisposition to taste food differently. Unfortunately, being a super-taster doesn’t make everything taste better. In fact, it can do the opposite. Super-tasters are extremely sensitive to bitterness, a common characteristic of many dark green, leafy veggies such as broccoli, cauliflower, cabbage and Brussels sprouts, to name a few. “The person who has that genetic propensity gets more of the sul...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News CNN Source Type: news
E-cigarettes may be more harmful to a smoker’s heart than traditional tobacco cigarettes. That’s the finding of new research from Cedars-Sinai Medical Center in Los Angeles, presented today (Nov. 11) at an American Heart Association scientific conference. The Cedars-Sinai team compared the hearts of 10 non-smokers to the hearts of 10 tobacco smokers and 10 e-cigarette smokers. All the people in the study were younger than 40, and all were otherwise healthy. In response to a mild bout of exercise, measures of blood flow increased in the hearts of the non-smokers. Among the tobacco smokers, this increase was blun...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized embargoed study heart health vaping Source Type: news
Publication date: December 2019Source: The Lancet Global Health, Volume 7, Issue 12Author(s): Geetha R Menon, Lucky Singh, Palak Sharma, Priyanka Yadav, Shweta Sharma, Shrikant Kalaskar, Harpreet Singh, Srividya Adinarayanan, Vasna Joshua, Vaitheeswaran Kulothungan, Jeetendra Yadav, Leah K Watson, Shaza A Fadel, Wilson Suraweera, M Vishnu Vardhana Rao, R S Dhaliwal, Rehana Begum, Prabha Sati, Dean T Jamison, Prabhat JhaSummaryBackgroundMany countries, including India, seek locally constructed disease burden estimates comprising mortality and loss of health to aid priority setting for the prevention and treatment of disease...
Source: The Lancet Global Health - Category: International Medicine & Public Health Source Type: research
Authors: Bluethmann SM, Foo W, Winkels RM, Mama SK, Schmitz KH Abstract PURPOSE: (a) To describe the relationship of multimorbidity and physical activity (PA) in cancer survivors and (b) to explore perceived disability and PA in middle-aged and older survivors. METHODS: The authors analyzed the data from cancer survivors (N = 566), identified using the Pennsylvania Cancer Registry, who responded to a Behavioral Risk Factor Surveillance System-derived questionnaire. They created age groups (e.g., 45-54 years, 55-64 years, 65-74 years, and 75 years and older) and calculated a composite score of eig...
Source: Journal of Aging and Physical Activity - Category: Geriatrics Tags: J Aging Phys Act Source Type: research
In 1992, Anthony Pelosivoiced concerns in the British Medical Journal about controversial findings from Hans Eysenck – one of the most influential British psychologists of all time – and German researcher Ronald Grossarth-Maticek. Those findings claimed personality played a bigger part in people’s chances of dying from cancer or heart disease than smoking. Almost three decades later, Eysenck’s institution have recommended these studiesbe retracted from academic journals.Hannah Devlin speaks to Pelosi about the twists and turns in his ultimately successful journey. And to the Guardian ’s health...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Psychology Science Health Smoking Tobacco industry Society Source Type: news
CONCLUSIONS AND IMPLICATIONS FOR PUBLIC HEALTH PRACTICE: Efforts that prevent adverse childhood experiences could also potentially prevent adult chronic conditions, depression, health risk behaviors, and negative socioeconomic outcomes. States can use comprehensive public health approaches derived from the best available evidence to prevent childhood adversity before it begins. By creating the conditions for healthy communities and focusing on primary prevention, it is possible to reduce risk for adverse childhood experiences while also mitigating consequences for those already affected by these experiences. PMID: 316...
Source: MMWR Morb Mortal Wkl... - Category: Epidemiology Authors: Tags: MMWR Morb Mortal Wkly Rep Source Type: research
This report enhances the geographic detail by using the six levels of the 2013 National Center for Health Statistics (NCHS) urban-rural classification scheme for counties and extending estimates of potentially excess deaths by annual percent change (APC) and for additional years (2010-2017). Trends were tested both with linear and quadratic terms. PERIOD COVERED: 2010-2017. DESCRIPTION OF SYSTEM: Mortality data for U.S. residents from the National Vital Statistics System were used to calculate potentially excess deaths from the five leading causes of death among persons aged
Source: MMWR Surveill Summ - Category: Epidemiology Authors: Tags: MMWR Surveill Summ Source Type: research
Abstract Orthostatic hypotension (OH) is a cardinal sign of cardiovascular (CV) autonomic dysfunction as a result of autonomic nervous system failure to control the postural hemodynamic homeostasis. The proportion of individuals with OH increases with aging and chronic conditions, such as neurodegenerative diseases, hypertension, heart failure, diabetes, renal dysfunction, autoimmune diseases and cancer. In those over 70 years, more than 20% can be affected. It is now increasingly recognized that a direct relationship exists between OH and each step of the CV disease continuum, eventually leading to end-stage hear...
Source: Polish Heart Journal - Category: Cardiology Authors: Tags: Kardiol Pol Source Type: research
Nonmetropolitan, or rural, counties have more preventable deaths from cancer, heart disease, unintentional injury, chronic lower respiratory disease, and stroke than metropolitan, or urban, counties.
Source: CDC Morbidity and Mortality Weekly Report - Category: American Health Tags: Cancer Heart Disease Injury Statistics MMWR Morbidity & Mortality Weekly Report Stroke Source Type: news
THURSDAY, Nov. 7, 2019 -- Rural Americans die more often from potentially preventable causes than their urban counterparts, a new government study shows. These causes include cancer, heart disease, injury, respiratory disease and stroke, according...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
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