Extensive cerebellar and thalamic degeneration in spinocerebellar ataxia type 10
Spinocerebellar ataxia type 10 (SCA10) is a hereditary neurodegenerative disorder caused by repeat expansions in the ATXN10 gene. Patients present with cerebellar ataxia frequently accompanied by seizures. Even though loss of cerebellar Purkinje neurons has been described, its brain degeneration pattern is unknown. Our aim was to characterize the gray and white matter degeneration patterns in SCA10 patients and the association with clinical features.
Source: Parkinsonism and Related Disorders - Category: Neurology Authors: Carlos R. Hernandez-Castillo, Rosalinda Diaz, Israel Vaca-Palomares, Diana L. Torres, Amanda Chirino, Aurelio Campos-Romo, Adriana Ochoa, Astrid Rasmussen, Juan Fernandez-Ruiz Source Type: research