The role of PSGL-1 in pathogenesis of systemic inflammatory response and coagulopathy in endotoxemic mice

Endotoxemia often results in systemic inflammatory response syndrome (SIRS), coagulation disturbance and acute lung injury (ALI), and such a condition is associated with the activation of platelets, leukocytes and vascular endothelial cells (VECs). P-selectin glycoprotein ligand 1 (PSGL-1) is a key regulatory molecule in the activation of platelets, leukocytes and VECs. However, it still remains largely unexplored whether PSGL-1 plays an important role in SIRS, coagulation dysfunction and ALI of endotoxemia.

Source: Thrombosis Research - August 18, 2019 Category: Hematology Authors: Xiao-li Wang, Hua-fei Deng, Chu-yi Tan, Zi-hui Xiao, Mei-dong Liu, Ke Liu, Hua-li Zhang, Xian-zhong Xiao Tags: Full Length Article Source Type: research