Low-dose nivolumab induced durable complete response in relapsed primary central nervous system diffuse large B cell lymphoma

Source: Annals of Hematology - Category: Hematology Source Type: research

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Oligosaccharides of glycoprotein, particularly negatively-charged sialylated N-glycans, on the surface of lymphomas play important roles in cell –cell interactions and bind immunoglobulin-like lectins, causing inf...
Source: BMC Cancer - Category: Cancer & Oncology Authors: Tags: Research article Source Type: research
AbstractBackground.Primary central nervous system lymphoma (PCNSL) is a rare subtype of extranodal lymphoma. Despite established clinical prognostic scoring such as that of the Memorial Sloan Kettering Cancer Center (MSKCC) and the International Extranodal Lymphoma Study Group, outcome prediction needs to be improved. Several studies have indicated an association between changes in hematologic laboratory parameters with patient outcomes in PCNSL. We sought to assess the association between hematological parameters and overall survival (OS) in patients with PCNSL.Methods.Pretreatment blood tests were analyzed in patients wi...
Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Lymphoma, Neuro-Oncology Hematologic Malignancies Source Type: research
Condition:   Primary Central Nervous System Lymphoma Intervention:   Drug: rituximab in combination with methotrexate, cytarabine and dexamethasone Sponsor:   Mingzhi Zhang Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
AbstractMonomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) is a provisional entity in the 2017 World Health Organization classifications. To further elucidate the clinicopathologic features of this new disease, we carried out a retrospective, multicenter analysis of 42 patients with MEITL. The median age of the patients was 59  years (range, 20–84 years), and 27 patients (64 %) were male. Thirty-two patients (76 %) were Ann-Arbor stages I–II and 28 (67 %) were Lugano stages I–II1&2. The most frequent site of involvement was the jejunum (N = 21). Most case...
Source: Annals of Hematology - Category: Hematology Source Type: research
CONCLUSIONS: Similar to results for non-preload-based DSC-MR imaging, percentage signal recovery for one-quarter-dose preload-based, intermediate flip angle DSC-MR imaging differentiates most pair-wise comparisons of glioblastoma, metastasis, primary central nervous system lymphoma, and meningioma, except for glioblastoma versus metastasis. Differences in normalized post-preload baseline signal for glioblastoma and metastasis, reflecting a snapshot of dynamic contrast enhancement, may motivate the use of single-dose multiecho protocols permitting simultaneous quantification of DSC-MR imaging and dynamic contrast-enhanced M...
Source: American Journal of Neuroradiology - Category: Radiology Authors: Tags: FUNCTIONAL Source Type: research
Condition:   Primary Central Nervous System Lymphoma Intervention:   Drug: Camrelizumab Sponsor:   Beijing Sanbo Brain Hospital Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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