Cancers, Vol. 11, Pages 1207: Tumor Cell Dormancy: Threat or Opportunity in the Fight against Cancer

Cancers, Vol. 11, Pages 1207: Tumor Cell Dormancy: Threat or Opportunity in the Fight against Cancer Cancers doi: 10.3390/cancers11081207 Authors: Rana Jahanban-Esfahlan Khaled Seidi Masoud H. Manjili Ali Jahanban-Esfahlan Tahereh Javaheri Peyman Zare Tumor dormancy, a clinically undetectable state of cancer, makes a major contribution to the development of multidrug resistance (MDR), minimum residual disease (MRD), tumor outgrowth, cancer relapse, and metastasis. Despite its high incidence, the whole picture of dormancy-regulated molecular programs is far from clear. That is, it is unknown when and which dormant cells will resume proliferation causing late relapse, and which will remain asymptomatic and harmless to their hosts. Thus, identification of dormancy-related culprits and understanding their roles can help predict cancer prognosis and may increase the probability of timely therapeutic intervention for the desired outcome. Here, we provide a comprehensive review of the dormancy-dictated molecular mechanisms, including angiogenic switch, immune escape, cancer stem cells, extracellular matrix (ECM) remodeling, metabolic reprogramming, miRNAs, epigenetic modifications, and stress-induced p38 signaling pathways. Further, we analyze the possibility of leveraging these dormancy-related molecular cues to outmaneuver cancer and discuss the implications of such approaches in cancer treatment.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research