Oral vancomycin treatment does not alter markers of postprandial inflammation in lean and obese subjects

Translocation of intestinal bacteria into the blood is implicated in the systemic inflammatory response that occurs after a high fat meal. We showed that after gut microbiota manipulation with vancomycin, the postprandial inflammatory phenotype in lean and obese subjects is unaffected, despite major vancomycin ‐induced disruption of the gut microbiota and increased fasting plasma LPS. This suggests that bacterial translocation may not play a large role in postprandial inflammation. AbstractIntake of a high ‐fat meal induces a systemic inflammatory response in the postprandial which is augmented in obese subjects. However, the underlying mechanisms of this response have not been fully elucidated. We aimed to assess the effect of gut microbiota modulation on postprandial inflammatory response in lean and obese subjects. Ten lean and ten obese subjects with metabolic syndrome received oral vancomycin 500 mg four times per day for 7 days. Oral high‐fat meal tests (50 g fat/m2 body surface area) were performed before and after vancomycin intervention. Gut microbiota composition, leukocyte counts, plasma lipopolysaccharides (LPS), LPS ‐binding protein (LBP), IL‐6 and MCP‐1 concentrations and monocyte CCR2 and cytokine expression were determined before and after the high‐fat meal. Oral vancomycin treatment resulted in profound changes in gut microbiota composition and significantly decreased bacterial diversity in both gro ups (phylogenetic diversity pre...
Source: Physiological Reports - Category: Physiology Authors: Tags: Original Research Source Type: research

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Source: Acta Clinica Croatica - Category: General Medicine Tags: Acta Clin Croat Source Type: research
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Source: Acta Clinica Croatica - Category: General Medicine Tags: Acta Clin Croat Source Type: research
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Source: Acta Clinica Croatica - Category: General Medicine Tags: Acta Clin Croat Source Type: research
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Source: Journal of Biosciences - Category: Biomedical Science Authors: Tags: J Biosci Source Type: research
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Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
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Source: Clinical Epidemiology and Global Health - Category: Epidemiology Source Type: research
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Source: Clinical Epidemiology and Global Health - Category: Epidemiology Source Type: research
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Source: Journal of Functional Foods - Category: Nutrition Source Type: research
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Source: Journal of Functional Foods - Category: Nutrition Source Type: research
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Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Tags: 35 Source Type: research
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