"It's my own fault": accounts and consequences of falling when living with rheumatoid arthritis - Graham K, Birt L, MacGregor A, Watts L, Poland F.

INTRODUCTION: Rheumatoid arthritis (RA) leads to biomechanical joint changes, which increases the risk of falling. The consequence of falling may be physical injury. However, the psychological consequences, including the fear of falling, can be equally imp...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news

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Publication date: Available online 17 September 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Andrew B. Wolf, Lana Zhovtis Ryerson, Krupa Pandey, Brett M. McGettigan, Timothy Vollmer, John R. Corboy, Enrique AlvarezAbstractRituximab is a chimeric anti-CD20 monoclonal antibody that is an effective therapy for multiple sclerosis. Rituximab has been associated with the development of serum sickness (type III hypersensitivity) characterized by arthralgia, fever, and rash during the treatment of other conditions, such as rheumatoid arthritis. Here we describe serum sickness associated with rituximab in multiple...
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Publication date: Available online 18 September 2019Source: Revista Portuguesa de Cardiologia (English Edition)Author(s): Isabel Durães Campos, Ana Rita Marques, Luciana Sousa, Sara Fonseca, Cátia Oliveira, Catarina Vieira, Isabel Apolinário, Ilídio BrandãoAbstractAn 83-year-old woman with a 10-year history of rheumatoid arthritis was admitted for urinary tract infection with exacerbation of chronic kidney disease and decompensated heart failure of unknown etiology. Transesophageal echocardiography (TEE) showed a vegetation involving the posterior mitral valve leaflet, and a hypothesis of...
Source: Revista Portuguesa de Cardiologia - Category: Cardiology Source Type: research
Authors: Martinez-Prat L, Palterer B, Vitiello G, Parronchi P, Robinson WH, Mahler M Abstract Introduction: The protein-arginine deiminase (PAD) 4 enzyme plays an important role in the pathogenesis of rheumatoid arthritis (RA) and also represents an antigenic target. Anti-PAD4 antibodies can be present in RA and are associated with specific clinical features. Areas covered: This review aims to analyze the current knowledge and recent findings on anti-PAD4 antibodies in RA and their clinical and immunological significance. Expert opinion: Anti-PAD4 antibodies aren't currently used in clinical practice for the manage...
Source: Expert Review of Clinical Immunology - Category: Allergy & Immunology Tags: Expert Rev Clin Immunol Source Type: research
This case report describes a series of patients with refractory chronic pruritus of unknown origin and rheumatoid arthritis who were treated with tofacitinib.
Source: JAMA Dermatology - Category: Dermatology Source Type: research
Accumulating studies have suggested that long non-coding RNAs (lncRNAs) have drawn more and more attention in rheumatoid arthritis (RA), which can function as competitive endogenous RNAs (ceRNAs) in inflammation and immune disorders. Previously, we have found that lncRNA HIX003209 is differentially expressed in RA. However, the precise mechanism of lncRNA HIX003209 in RA is still vague. We aim to elucidate the role and its targeted microRNA of lncRNA HIX003209 in RA as ceRNA. Significantly increased expression of lncRNA HIX003209 was observed in the peripheral blood mononuclear cells (PBMCs) from RA cases. It was positivel...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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Source: Expert Opinion on Biological Therapy - Category: Drugs & Pharmacology Authors: Source Type: research
This article is retrospective consecutive series of 110 valgus knees using CR implants with a minimum 2-year follow-up. Deformity correction was achieved using stepwise sequential soft tissue releases (iliotibial band, popliteus tendon, lateral collateral release through sliver femoral condylar osteotomy). Demographic data, range of movement, and degrees of deformity were collected. The Oxford Knee Score (OKS) was used as patients' reported outcome measure at final follow-up. One-hundred and four patients (110 knees) were included (87 females/17 males) with mean age of 68.7 years. Primary diagnosis was osteoarthritis in 85...
Source: Journal of Knee Surgery - Category: Orthopaedics Authors: Tags: Original Article Source Type: research
The ankyrin repeat domain-55 (ANKRD55) gene contains intronic single nucleotide polymorphisms (SNPs) associated with risk to contract multiple sclerosis, rheumatoid arthritis or other autoimmune disorders. Risk alleles of these SNPs are associated with higher levels of ANKRD55 in CD4+ T cells. The biological function of ANKRD55 is unknown, but given that ankyrin repeat domains constitute one of the most common protein-protein interaction platforms in nature, it is likely to function in complex with other proteins. Thus, identification of its protein interactomes may provide clues. We identified ANKRD55 interactomes via rec...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Publication date: Available online 17 September 2019Source: Reumatología Clínica (English Edition)Author(s): Carola Baliu-Piqué, Elena Nogués-Antich, Marta Cucurell-Palomas, Dolors Grados
Source: Reumatologia Clinica - Category: Rheumatology Source Type: research
Publication date: Available online 16 September 2019Source: Pharmacological ResearchAuthor(s): Fabiola Atzeni, Valeria Nucera, Ignazio Francesco Masala, Piercarlo Sarzi-Puttini, Gianluca BonittaABSTRACTInterleukin 6 (IL-6) is a pleiotropic cytokine that plays a role in the neuroendocrine system, insulin resistance, lipid metabolism, vascular disease, mitochondrial activities, neuropsychological behaviour, and also mediates communications between the immune and central nervous system (CNS). Treatment with anti-IL-6 or anti-IL-6R agents seems to alleviate allodynia and hyperalgesia, so it may be a valid option when treating ...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
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