Partial-Breast Irradiation: Review of Modern Trials

AbstractPurpose of ReviewFollowing partial mastectomy, whole-breast irradiation (WBI), delivered over 3 to 6  weeks, has been the standard adjuvant radiation approach for early-stage breast cancer. A growing body of literature over the past decade has suggested that irradiation of the partial breast, including the tumor bed plus a margin, may be a suitable alternative for appropriately selected patients. The use of partial breast irradiation (PBI) has been studied in multiple prospective randomized trials, now with up to 10 years of follow-up, establishing similar safety and efficacy compared with WBI. Advantages of PBI include (1) reduced treatment duration, (2) potential reductions in treatment-r elated toxicity, (3) improved cosmetic outcomes, and (4) reduced costs. The purpose of this article is to review appropriate patient selection criteria, clinical and toxicity outcomes data, clinical consensus practice guidelines, and the various PBI techniques.Recent FindingsThe National Surgical Adjuvant Breast and Bowel Project (NSABP) B39/Radiation Therapy Oncology Group (RTOG) 0413 study (NRG Oncology) is the most recently published (abstract form only) prospective randomized trial comparing PBI using 3D conformal external beam radiation therapy (3D-CRT, 38.5  Gy/10 fractions, twice daily) or brachytherapy (interstitial catheters or applicator based, 34 Gy/10 fractions, twice daily), vs. WBI (50 Gy ± tumor a bed boost). With a median follow-up of...
Source: Current Breast Cancer Reports - Category: Cancer & Oncology Source Type: research

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Source: Journal of Biosciences - Category: Biomedical Science Authors: Tags: J Biosci Source Type: research
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Source: Journal of Biosciences - Category: Biomedical Science Authors: Tags: J Biosci Source Type: research
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Source: Inorganica Chimica Acta - Category: Chemistry Source Type: research
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Source: Minerva Endocrinologica - Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
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Source: Journal of Functional Foods - Category: Nutrition Source Type: research
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Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Tags: 252 Source Type: research
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Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
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Source: BBC News | Health | UK Edition - Category: Consumer Health News Source Type: news
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Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research
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