Akt is a critical node of acute myocardial insulin resistance and cardiac dysfunction after cardiopulmonary bypass

Publication date: Available online 5 August 2019Source: Life SciencesAuthor(s): Zhifa Wang, Yunya Wang, Yuehu Han, Qiang Yin, Sheng Hu, Ting Zhao, Tao Chen, Heng Ma, Chunhu GuAbstractAimsAcute myocardial insulin resistance is an independent risk factor for patients who undergo cardiac surgery with cardiopulmonary bypass (CPB). However, the underlying mechanism of insulin resistance during CPB has not been fully investigated.Materials and methodsTo explore the role of myocardial insulin resistance on the cardiac function and its underlying mechanism, CPB operation and pharmacological intervention were applied in mini pigs, and myocardial insulin signaling, glucose uptake, ATP production and cardiac function were examined.Key findingsOur data showed that CPB elicited not only hyperglycemia and hyperinsulinemia, but also inactivated Akt, and impaired the transposition of membrane glucose transporter-4 (GLUT-4), reduced glucose uptake and ATP production in the myocardium as well, which in turn was accompanied with cardiac dysfunction. Meanwhile, linear correlations were established among reduced myocardial glucose uptake, ATP production, and depressed cardiac systolic or diastolic function. Reactivation of Akt by SC79, an Akt agonist, partially alleviated myocardial insulin resistance and restored post CPB cardiac function via augmenting myocardial glucose uptake and ATP production.SignificanceThese findings revealed that acute myocardial insulin resistance due to inactivation of...
Source: Life Sciences - Category: Biology Source Type: research

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Authors: Gawlinska K, Gawlinski D, Przegalinski E, Filip M Abstract A balanced maternal diet is necessary for the proper health and development of offspring. Recent clinical and preclinical studies have strongly indicated that maternal exposure to a high-fat diet (HFD) can have an irreversible impact on the structure and function of the offspring's brain and affect the immune system, which may predispose the offspring to brain disorders, including depression. The irisin/brain-derived neurotrophic factor (BDNF) axis is a pathway that influences several neurobehavioral mechanisms involved in the pathogenesis of menta...
Source: Journal of Physiology and Pharmacology - Category: Drugs & Pharmacology Tags: J Physiol Pharmacol Source Type: research
[Paternal depression in a "stay-at-home" father - case report]. Neuropsychopharmacol Hung. 2019 Sep;21(3):136-141 Authors: Hajnaczky L, Lazary J Abstract There is a growing body of data on paternal peripartum depression (perinatal depression in father; PND-F), however, it has traditionally been investigated only in women. Recently accumulating results confirmed the prominent role of the mental health of fathers in the psychosocial development of children and new trends showed up concerning the father's role in the family. In this case report we demonstrate the clinical aspect of a depressive ...
Source: Neuropsychopharmacologia Hungarica - Category: Psychiatry Tags: Neuropsychopharmacol Hung Source Type: research
Authors: Zonda T, Paksi B, Bozsonyi K, Veres E Abstract In our study we have summarised the various fields of our suicide research made in the last 40 years. We have devided our whole publications into thematic chapters: cultural-history, regional differences, follow-up studies, prenvention, ecological researches, mostly sociology. Some of them had been firstly published in Hungarian or/and also in international literature. We repeatedly reiterate the importance of writing a Hungarian suicide prevention program. We agree with the opinion: "Suicide prevention is far more than a psychiatric business". P...
Source: Neuropsychopharmacologia Hungarica - Category: Psychiatry Tags: Neuropsychopharmacol Hung Source Type: research
[Cariprazine, a new type - dopamine Dā‚ƒ receptor preferring - partial agonist atypical antipsychotic for the treatment of schizophrenia and the primary negative symptoms]. Neuropsychopharmacol Hung. 2019 Sep;21(3):103-118 Authors: Laszlovszky I, Kiss B, Barabassy A, Kapas M, Nemeth G Abstract Dopamine Dā‚‚ receptor partial agonists represent a new generation of atypical antipsychotics. Cariprazine, which has received centralized market authorization from the European Medicines Agency in 2017 for the treatment of adult patients with schizophrenia (including those with predominant negative symptoms of s...
Source: Neuropsychopharmacologia Hungarica - Category: Psychiatry Tags: Neuropsychopharmacol Hung Source Type: research
Publication date: Available online 20 September 2019Source: Journal of Herbal MedicineAuthor(s): Ying Wang, Yu-Jie Liu, Feng-E Li, Zhi Guo, Jun Wang, Comorbid Depression and Coronary Heart Disease Research Group of Cangzhou Central HospitalAbstractDepression is one of the major risk factors for the development, progression and prognosis of coronary heart disease (CHD). Patients with depression and CHD have high mortality and morbidity. Conventional antidepressant therapies achieve limited success in CHD patients. The aim of the present study was to determine the efficacy of a formulation of Chinese herbal medicine called t...
Source: Journal of Herbal Medicine - Category: Complementary Medicine Source Type: research
ConclusionThe findings of the randomized and sham-controlled trial will demonstrate that acupuncture therapy is effective and safe for patients with PPD through probablly regulating the gut microbiota dysfunction. These findings might have an important impact on the practice of acupuncture for patients with PPD.
Source: European Journal of Integrative Medicine - Category: Complementary Medicine Source Type: research
Official advice from the drug regulator is a victory for The Mail on Sunday, after we revealed that many patients, including children, said that montelukast had deeply affected their behaviour.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Publication date: October 2019Source: European Psychiatry, Volume 62Author(s): Leah Shelef, Ishai Nir, Lucian Tatsa-Laur, Ron Kedem, Niv Gold, Tarif Bader, Ariel Ben YehudaAbstractBackgroundSuicide is major cause of death in the IDF. The Suicide Prevention Program (SPP) led to significant reduction in yearly rates of suicide. A study regarding demographic changes of those who died by suicide was done to further investigate its affect.MethodNested case control retrospective study based on medical and HR data gathered between 1992 and 2016. Participants were divided into four groups: soldiers who died by suicide and non-suic...
Source: European Psychiatry - Category: Psychiatry Source Type: research
at Knechtle Since the prevalence of depression is high among athletes at the end of their athletic career, the purpose of this study was to investigate the effect of time-of-day-exercise in group settings on the level of the mood and depression of former elite male athletes.Out of 187 volunteers referring to the sports counseling clinic, 71 retired male athletes who had a national championship record were randomly divided into two morning and evening exercise groups. The inclusion criteria were severe depression (high score in the Beck Depression Inventory-II), the age range of 50 to 60 years, the absence of metabolic ...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
CONCLUSIONS: Advance and concurrent request EAS cases differ in age, duration of illness, and past experience. Advance request EAS cases were complicated by ambiguous directives, patients being unaware of the EAS procedure, and physicians' difficulty assessing "unbearable suffering." Notably, some concurrent request patients were quite impaired yet deemed competent by appeals to previous statements. PMID: 31537470 [PubMed - as supplied by publisher]
Source: The American Journal of Geriatric Psychiatry - Category: Psychiatry Tags: Am J Geriatr Psychiatry Source Type: research
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