The influence of apocynin, lipoic acid and probiotics on antioxidant enzyme levels in the pulmonary tissues of obese asthmatic mice

Publication date: Available online 17 August 2019Source: Life SciencesAuthor(s): Paulina Kleniewska, Rafal PawliczakAbstractBronchial asthma and obesity are common health problems. Obesity is already responsible for 300,000 deaths per year.AimsThe aim of the present study was to assess whether apocynin, alpha lipoic acid and probiotic administration in combination with low-fat diet supplementation influences the levels of antioxidant enzymes in the pulmonary tissues of obese asthmatic mice.Main methodsThe study was performed on male C57/BL6 mice divided into 10 groups: (I) control; (II) asthma; (III) obesity; (IV) asthma + obesity; (V) asthma + obesity + apocynin p.o. 15 mg/kg/day for 12 weeks; (VI) asthma + obesity + low-fat diet for 12 weeks; (VII) asthma + obesity + low-fat diet for 12 weeks with apocynin p.o. 15 mg/kg/day; (VIII) asthma + obesity + low-fat diet with probiotics for 12 weeks; (IX) asthma + obesity + low-fat diet for 12 weeks with lipoic acid p.o. 100 mg/kg/day for 12 weeks; (X) asthma + obesity + standard diet with probiotics for 12 weeks. Superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GR) activity were examined. The administration of apocynin alone and apocynin in combination with a low-fat diet resulted in a significant increase in SOD values (respectively p 
Source: Life Sciences - Category: Biology Source Type: research

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In conclusion, the findings of this study suggest that excess body weight could impact pulmonary dynamics in childhood asthma.
Source: Lung - Category: Respiratory Medicine Source Type: research
Starting the night shift and this case came in 2 hours prior to my arrival: 25 yo G1P0 @ 39 week gestation, BMI 77, 210 kg, admitted for attempted IOL for fetal macrosomia and super morbid obesity. PMH: - Likely OSA, PSG scheduled in 3 weeks. Can lie flat and breathe comfortably if awake but sleeps on side at night due to waking up from obstruction. Worse since pregnancy. - Mild intermittent asthma, uses inhaler 1-2x every 2 weeks. Worse since being pregnant. - Chiari 1 malformation dx'd 2... OB Case
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Anesthesiology Source Type: forums
AbstractPurpose of ReviewRising costs and increasing morbidity makes the identification and treatment of high-risk asthma phenotypes important. In this review, we outline the complex relationship between obesity and asthma.Recent FindingsStudies have confirmed a bi-directional relationship between obesity and asthma. Pathophysiological factors implicated include genetic risk, the effect of diet and microbiome, and obesity-related cytokines. There have been robust, albeit derived, efforts to phenotype this group with distinct clinical presentations based on age of onset of asthma. Unfortunately, the poor performance of biom...
Source: Current Allergy and Asthma Reports - Category: Allergy & Immunology Source Type: research
Factors long before conception may increase risk for asthma, and male puberty is a time window of particular importance. In our study, overweight onset in boys in puberty was associated with asthma in future offspring.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research
AbstractPurpose of ReviewAsthma, a common respiratory disease that affects about 10% of the US population, represents a significant public health issue. In the last decade, cumulative evidence has demonstrated sex disparities in asthma, including significant differences in epidemiology, clinical presentation, response to therapies, and health outcomes. Understanding sex-related differences in asthma enables clinicians to provide personalized asthma care and improve asthma outcome.Recent FindingsRecent studies on sex-related differences in asthma inform us on mechanism underlying asthma pathogenesis across all age groups. S...
Source: Current Allergy and Asthma Reports - Category: Allergy & Immunology Source Type: research
Conclusions: In an Indian cohort of well-characterized patients with asthma, cluster analysis identified four distinct clinical phenotypes of asthma, two of which had poor attainment of maximum lung functions. PMID: 31479309 [PubMed - as supplied by publisher]
Source: Journal of Asthma - Category: Respiratory Medicine Tags: J Asthma Source Type: research
AbstractPurpose of ReviewReports of respiratory symptoms, including asthma and hyper-reactive airway disease, have been more numerous in the media and medical literature since active duty service members (SM) began to support campaigns in South West Asia (SWA). Numerous environmental exposures have been reported and this review assesses the available evidence surrounding exposures, confounding conditions, and attempts to develop screening mechanisms.Recent FindingsWhile particulate matter exposures and particularly exposure to burn pits have garnered much attention, a 2010 Armed Forces Health Surveillance Center report and...
Source: Current Allergy and Asthma Reports - Category: Allergy & Immunology Source Type: research
Abstract Motivational interviewing (MI) addresses patient ambivalence about a desired goal in a directed, patient-centered manner. MI intervention is established as a therapeutic tool within the pediatric population with positive outcomes for obesity, asthma, medication adherence, and HIV management. MI is especially promising within the adolescent population where increasing independence tends to contribute to poorer health outcomes. Multidisciplinary adaptation of the MI format works well to address traditionally difficult pediatric care issues such as obesity. In the future, MI training of physicians may incorp...
Source: Pediatric Annals - Category: Pediatrics Authors: Tags: Pediatr Ann Source Type: research
Publication date: November 2019Source: Japanese Dental Science Review, Volume 55, Issue 1Author(s): Kentaro Mizuta, Atsuko Matoba, Sumire Shibata, Eiji Masaki, Charles W. Emala SrAbstractObesity is a major risk factor for the development of asthma, and worsens the key features of asthma including airway hyperresponsiveness, inflammation, and airway remodeling. Although pro- and anti-inflammatory adipocytokines may contribute to the pathogenesis of asthma in obesity, the mechanistic basis for the relationship between asthma and obesity remains unclear. In obese individuals, the increased amount of adipose tissue results in ...
Source: Japanese Dental Science Review - Category: Dentistry Source Type: research
Authors: Kalicki B, Lipińska-Opałka A, Kowalczyk K, Mycroft K, Królikowska J, Rustecka A, Wawrzyniak A Abstract The prevalence of allergy and obesity is sharply on the rise in children. However, the nature of a mutual relation of the two conditions remains unclear. The aim of the study was to assess the impact of excessive body weight on the immune response in children with allergies. There were 56 children with allergies, aged 4-15 years, included into the study (41 with asthma and 15 with atopic dermatitis). Based on the body mass index, children were divided into two groups: normal weight (body mass index (BMI)
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
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