The dipeptidyl peptidase 4 inhibitor sitagliptin improves oxidative stress and ameliorates glomerular lesions in a rat model of type 1 diabetes
Publication date: 1 October 2019Source: Life Sciences, Volume 234Author(s): Catarina Marques, Andreia Gonçalves, Patrícia Manuela Ribeiro Pereira, Daniela Almeida, Beatriz Martins, Carlos Fontes-Ribeiro, Flávio Reis, Rosa FernandesAbstractAimsOxidative stress has been linked to the development and progression of diabetic nephropathy (DN). The present study evaluated whether the dipeptidyl peptidase-4 inhibitor sitagliptin attenuates glomerular lesions and oxidative stress evoked by chronic hyperglycemia, by a mechanism independent of insulin secretion and glycemia normalization.Main methodsA rat model of DN caused by streptozotocin injection was established and the effects of sitagliptin (5 mg/kg/day) were evaluated after two weeks of treatment.Key findingsSitagliptin treatment did not change body weight, glycemic and lipid profiles. However, histopathological observation revealed that sitagliptin attenuates diabetes-induced glomerular lesions on diabetic rats. Sitagliptin also ameliorated the increase in DPP-4 content and promoted the stabilization of GLP-1 in the diabetic kidney. Furthermore, sitagliptin treatment significantly attenuated the increase of free-radical formation and the decrease of antioxidant defenses, attenuating therefore the oxidative stress in the kidneys of diabetic animals.SignificanceThe results suggest that sitagliptin treatment alleviates kidney oxidative stress in type 1 diabetic rats, which could play a key role in reducing ...
Conclusions: Under routine care, switching to degludec is dominant, compared with continuing previous basal insulin, in Italian patients with T1D or T2D. PMID: 31526202 [PubMed - as supplied by publisher]
Authors: Xia J, Minamino S, Kuwabara K, Arai S Abstract Stem cells are an undifferentiated cell population that has the ability to develop into many different cell types and also has the ability to repair damaged tissues in some cases. For a long time, the stem cell regenerative paradigm has been based on the assumption that progenitor cells play a critical role in tissue repair by means of their plasticity and differentiation potential. However, recent works suggest that the mechanism underlying the benefits of stem cell transplantation might relate to a paracrine modulatory effect rather than the replacement of a...
This study analyzed the interaction effect of adolescents ’ family support, age, and gender in the relationship between adherence and glycemic control in adolescents with Type 1 Diabetes. The sample included 100 adolescents with Type 1 Diabetes and one of their parents during a routine endocrinology appointment. Adolescents answered the Self-Care Invento ry—Revised, the Diabetes Family Behavior Scale and were also assessed on the glycosylated hemoglobin. The three-way interaction between adherence, family support, and adolescents’ age/gender was both negatively significant and explained 24.12% and 22.02% ...
Condition: Type 1 Diabetes Intervention: Device: Jet Injector without A Needle Sponsor: Second Xiangya Hospital of Central South University Not yet recruiting
Publication date: October 2019Source: Canadian Journal of Diabetes, Volume 43, Issue 7, SupplementAuthor(s): Fiona Thompson-Hutchison, ILANA J. Halperin, Sapida Adib, Mary Elizabeth Nguyen, Karen Cox, Deanna Palazzo, Michael Houlahan
Publication date: October 2019Source: Canadian Journal of Diabetes, Volume 43, Issue 7, SupplementAuthor(s): Ellen B. Goldbloom, Shannon Nelson, Annie Garon-Mailer, Janine Malcolm
Publication date: October 2019Source: Canadian Journal of Diabetes, Volume 43, Issue 7, SupplementAuthor(s): Alanna Weisman, Karen Tu, Jacqueline Young, Matthew Kumar, Peter C. Austin, Liisa Jaakkimainen, Lorraine L. Lipscombe, Ronnie Aronson, Gillian L. Booth
Publication date: October 2019Source: Canadian Journal of Diabetes, Volume 43, Issue 7, SupplementAuthor(s): Leif Erik Lovblom, Nancy Cardinez, Andrej Orszag, Alanna Weisman, Vera Bril, David Cherney, Bruce A. Perkins
Publication date: October 2019Source: Canadian Journal of Diabetes, Volume 43, Issue 7, SupplementAuthor(s): Andrea Macintosh, Jacqueline L. Hay, Dessi P. Zaharieva, Veronica Jamnik, Michael C. Riddell, Normand G. Boulé, Jonathan M. Mcgavock, Jane E. Yardley