Molecules, Vol. 24, Pages 2991: Bioactivity of Methoxylated and Methylated 1-Hydroxynaphthalene-2-Carboxanilides: Comparative Molecular Surface Analysis
Molecules, Vol. 24, Pages 2991: Bioactivity of Methoxylated and Methylated 1-Hydroxynaphthalene-2-Carboxanilides: Comparative Molecular Surface Analysis
Molecules doi: 10.3390/molecules24162991
Authors:
Hana Michnová
Šárka Pospíšilová
Tomáš Goněc
Iva Kapustíková
Peter Kollár
Violetta Kozik
Robert Musioł
Izabela Jendrzejewska
Ján Vančo
Zdeněk Trávníček
Alois Čížek
Andrzej Bąk
Josef Jampílek
A series of twenty-six methoxylated and methylated N-aryl-1-hydroxynaphthalene- 2-carboxanilides was prepared and characterized as potential anti-invasive agents. The molecular structure of N-(2,5-dimethylphenyl)-1-hydroxynaphthalene-2-carboxamide as a model compound was determined by single-crystal X-ray diffraction. All the analysed compounds were tested against the reference strain Staphylococcus aureus and three clinical isolates of methicillin-resistant S. aureus as well as against Mycobacterium tuberculosis and M. kansasii. In addition, the inhibitory profile of photosynthetic electron transport in spinach (Spinacia oleracea L.) chloroplasts was specified. In vitro cytotoxicity of the most effective compounds was tested on the human monocytic leukaemia THP-1 cell line. The activities of N-(3,5-dimethylphenyl)-, N-(3-fluoro-5-methoxy-phenyl)- and N-(3,5-dimethoxyphenyl)-1-hydroxynaphthalene-2-carbox- amide were comparable with or even better than the commonly used standards ampicillin and isoniazid. All promising compounds did not...
Source: Molecules - Category: Chemistry Authors: Hana Michnov á Šárka Pospíšilová Tom áš Goněc Iva Kapust íková Peter Koll ár Violetta Kozik Robert Musio ł Izabela Jendrzejewska J án Vančo Zden ěk Trávníček Alois Čížek Andrzej B ąk Josef Jamp ílek Tags: Article Source Type: research
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