MiR-188-5p and MiR-141-3p Influence Prognosis of Bladder Cancer and Promote Bladder Cancer Synergistically

Publication date: Available online 17 August 2019Source: Pathology - Research and PracticeAuthor(s): X.X. Yang, P. WangAbstractMicroRNA (miRNA) plays a significant role in suppressing the occurrence and development of tumor by inhibiting the translation of target proteins. Although previous researches have verified many miRNAs’ functions in bladder cancer (BC), the function of miR-188-5p and miR-141-3p in BC still remains unknown. Our experiment manifested that miR-188-5p and miR-141-3p were highly expressed in BC tissues and cells, which indicated a poor prognosis. In vitro functional assays suggested that down-regulated miR-188-5p and miR-141-3p inhibited the proliferation, migration and invasion of BC cells, while a combination of half dose down-regulated miR-188-5p and half dose down-regulated miR-141-3p demonstrated a more obvious inhibition effect. All results indicated that miR-188-5p and miR-141-3p promoted BC respectively and synergistically. Therefore, miR-188-5p and miR-141-3p will not only assist the diagnosis of BC, but also serve as more effective joint markers to predict the progression of BC.
Source: Pathology Research and Practice - Category: Pathology Source Type: research

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Publication date: 1 December 2019Source: Materials Letters, Volume 256Author(s): Denggao Huang, Hui Cao, Lifang Guo, Yuanhui Gao, Linlin Zheng, Xiaohong Wen, Xiaolong Yu, Shufang ZhangAbstractA new way for prognosis of bladder cancer (BC) is to control the BC microenvironment by chemical groups. The self-assembled monolayer (SAM) surfaces with methyl (–CH3), hydroxyl (–OH) and carboxyl (–COOH) groups were prepared to control the UMUC-3 cells. The results indicated that all three kinds of chemical groups influenced the adhesion and the proliferation of UMUC-3 cells, and the apoptosis rate of UMUC-3 cells w...
Source: Materials Letters - Category: Materials Science Source Type: research
Authors: Yuk HD, Jeong CW, Kwak C, Kim HH, Ku JH Abstract Introduction: To investigate the correlation between preoperative De Ritis ratio (aspartate transaminase (AST)/alanine transaminase (ALT)) and postoperative outcome in patients with urothelial cell carcinoma (UC) treated with radical cystectomy. Materials and Methods: We analyzed the clinical and pathological data of 771 patients who underwent radical cystectomy for bladder UC. Patients were divided into two groups according to the optimal value of AST/ALT ratio. The effect of the AST/ALT ratio was analyzed using the Kaplan-Meier method and Cox regressio...
Source: Disease Markers - Category: Laboratory Medicine Tags: Dis Markers Source Type: research
In this study, we examined the effect of cordycepin on the proliferation and apoptosis of human bladder cancer T24 cells and its mechanism of action. Cordycepin treatment significantly reduced the cell survival rate of T24 cells in a concentration-dependent manner, which was associated with the induction of apoptosis. Cordycepin activated caspase-8 and -9, which are involved in the initiation of extrinsic and intrinsic apoptosis pathways, respectively, and also increased caspase-3 activity, a typical effect caspase, subsequently leading to poly (ADP-ribose) polymerase cleavage. Additionally, cordycepin increased the Bax/Bc...
Source: BioScience Trends - Category: Biomedical Science Tags: Biosci Trends Source Type: research
Publication date: Available online 17 September 2019Source: Urology Case ReportsAuthor(s): Lim HC, Khong TL, Ong TA, Roslani AC, Ang CWAbstractBladder perforation secondary to transurethral resection of bladder tumour (TURBT) increases the risk of tumour seeding and eventual extravesicle metastasis. Here we presented a case where a patient with localised bladder tumour was initially managed with repeated TURBT for tumour recurrence. Subsequently he was found to have extravesicle pelvic metastasis. This was likely secondary to microperforation of bladder and tumour seeding. Microscopic bladder perforation is difficult to di...
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research
Conclusions: In 3D brachytherapy of cervical cancer, GO and IPSA optimizations do not present a significant difference in target dose coverage; nevertheless, IPSA may reduce the maximum dose to normal tissue when compared with GO. PMID: 31523240 [PubMed]
Source: Journal of Contemporary Brachytherapy - Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research
Conclusions: When the facilities for MR-compatible applicators are not available, MR-based ISBT is feasible with PEEK catheters using available resources for advanced cervical cancer. Doses to HR-CTV and IR-CTV were achieved, restricting doses to OARs as per GEC-ESTRO guidelines. PMID: 31523230 [PubMed]
Source: Journal of Contemporary Brachytherapy - Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research
Publication date: 2019Source: European Urology Supplements, Volume 18, Issue 5Author(s): A. Fuentes-Bonachera, N.P. Kelly, D. Murray, G. McGuinness, W.P. Shields, I.M. Cullen, P.J. Daly
Source: European Urology Supplements - Category: Urology & Nephrology Source Type: research
Publication date: 2019Source: European Urology Supplements, Volume 18, Issue 5Author(s): S. O’Meara, S. Considine, S. Anderson, M. Aboelmagd, S. Connolly, D. Galvin, N. Hegarty, K.J. O’Malley
Source: European Urology Supplements - Category: Urology & Nephrology Source Type: research
Publication date: 2019Source: European Urology Supplements, Volume 18, Issue 5Author(s): N. O’Reilly, F. O’Brien, K. O’Connor
Source: European Urology Supplements - Category: Urology & Nephrology Source Type: research
Publication date: Available online 17 September 2019Source: European UrologyAuthor(s): Eugene Shkolyar, Xiao Jia, Timothy C. Chang, Dharati Trivedi, Kathleen E. Mach, Max Q.-H. Meng, Lei Xing, Joseph C. LiaoAbstractAdequate tumor detection is critical in complete transurethral resection of bladder tumor (TURBT) to reduce cancer recurrence, but up to 20% of bladder tumors are missed by standard white light cystoscopy. Deep learning augmented cystoscopy may improve tumor localization, intraoperative navigation, and surgical resection of bladder cancer. We aimed to develop a deep learning algorithm for augmented cystoscopic d...
Source: European Urology - Category: Urology & Nephrology Source Type: research
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