Cafeteria diet induces progressive changes in hypothalamic mechanisms involved in food intake control at different feeding periods in female rats

Publication date: Available online 17 August 2019Source: Molecular and Cellular EndocrinologyAuthor(s): Lazzarino Gisela Paola, Acutain María Florencia, Canesini Guillermina, Andreoli María Florencia, Ramos Jorge GuillermoAbstractWe studied the effects of cafeteria diet (CAF) intake from weaning on mRNA levels and DNA methylation state of feeding-related neuropeptides and hormone receptors in individual hypothalamic nuclei at different feeding periods. Four weeks of CAF (short-term) increased energy intake and adiposity, without affecting neuropeptides’ expression. Eleven weeks of CAF (medium-term) increased energy intake, adiposity, leptinemia, and body weight, with an orexigenic response of the lateral hypothalamus, paraventricular and ventromedial nuclei, given by upregulation of Orexins, AgRP, and NPY opposed by an anorectic signal of the arcuate nucleus, which displayed a higher POMC expression. The changes in neuropeptidic mRNA levels were related to epigenetic modifications in their promoter regions. Metabolic and molecular changes were intensified after 20 weeks of diet (long-term). The alterations in these hypothalamic brain nuclei could add information about their differential role in food intake control, and how their action is disrupted during the development of obesity.
Source: Molecular and Cellular Endocrinology - Category: Endocrinology Source Type: research

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ConclusionsEDA aggravates steatosis by striking balance between lipid deposition and elimination. It was a potential biomarker of NAFLD.
Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
CONCLUSIONS: Results of this study provide evidence that obesity affects the expression of the subset of genes related to immune response in the blood and that development of insulin resistance in obese adolescents is associated with strong down-regulation of the expressions of HLA-DRA, HLA-DRB1, HLA-F, and HLA-G genes, which may be contribute to the development of obesity complications. It is possible that transcription factor NFX1 and miR-190b participate in downregulation of HLA-DRA gene expression in the blood of obese adolescents with insulin resistance. PMID: 31517622 [PubMed - in process]
Source: Endocrine Regulations - Category: Endocrinology Tags: Endocr Regul Source Type: research
CONCLUSIONS: Results of this investigation provide evidence that insulin resistance in obese adolescents is associated with gene specific changes in the expression of IGF1, IGF2, IGFBP2, IGFBP5, IGFBP7, and HTRA1 genes and these changes possibly contribute to the development of glucose intolerance and insulin resistance. PMID: 31517621 [PubMed - in process]
Source: Endocrine Regulations - Category: Endocrinology Tags: Endocr Regul Source Type: research
Conclusions: Irisin levels do not differ after the onset of puberty thereafter with the progressing pubertal maturation. This may have important implications when using this adipomyokine in the future for diagnosis or treatment of obesity-related diseases. PMID: 31514491 [PubMed - as supplied by publisher]
Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology - Category: Endocrinology Tags: J Clin Res Pediatr Endocrinol Source Type: research
In this study we investigated these questions using eye-tracking and a two alternative forced food-choice task after measuring subjective values (attitude extremity) and their accompanying accessibility, certainty, and stability. Understanding this basic decision-making process is key if we are to gain insight on how to combat societal problems like obesity and other issues related to diet. We found that participants allocated more attention to items with lower attitude accessibility, but tended to choose items with higher attitude accessibility. Higher attitude certainty and stability had no effects on attention, but led ...
Source: Journal of Experimental Social Psychology - Category: Psychiatry & Psychology Source Type: research
Publication date: November 2019Source: Journal of Functional Foods, Volume 62Author(s): Ruiyu Wu, Xin Tang, Xincong Kang, Yushuang Luo, Lei Wang, Jian Li, Xiyang Wu, Dongbo LiuAbstractNumerous microbiotas, which play important roles in health, inhabit the human gut. A traditional Chinese medicine dietary therapy (TCMDT) diet, consisted of whole grains and traditional Chinese medicines, is traditionally used to lessen hyperglycemia and reduce obesity. The Simulator of the human intestinal microbial ecosystem (SHIME) was used for studying the effect of the TCMDT diet on gut microbiota and short chain fatty acids. The TCMDT d...
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
Publication date: Available online 14 September 2019Source: Journal of the Formosan Medical AssociationAuthor(s): Chih-Wei Sung, Chien-Hua Huang, Wen-Jone Chen, Wei-Tien Chang, Chih-Hung Wang, Yen-Wen Wu, Wei-Ting Chen, Jia-How Chang, Min-Shan TsaiBackgroundThe role of body mass index (BMI) in clinical outcomes in patients resuscitated from cardiac arrest (CA) has recently drawn attention. We evaluated the effect of BMI on the prognosis of patients successfully resuscitated from cardiogenic arrest.MethodsThis retrospective cohort study included 273 non-traumatic adult cardiogenic arrest survivors receiving coronary angiogr...
Source: Journal of the Formosan Medical Association - Category: General Medicine Source Type: research
A new report shows that nine states have adult obesity rates that equal or exceed 35%. Here is the breakdown by state.
Source: Healthcare News - Category: Pharmaceuticals Authors: Source Type: news
Publication date: September 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 9Author(s): Yao-Hao XU, Wei LI, Yong RAO, Zhi-Shu HUANG, Sheng YINAbstractBioassay-guided fractionation of an ethanolic extract of Ochrosia borbonica led to the isolation of two known pyridocarbazole alkaloids, ellipticine (1) and 9-methoxyellipticine (2), and six known monoterpenoid indole alkaloids (3–8). Lipid-lowering assay in 3T3-L1 cell model revealed that 1 and 2 could significantly inhibit the lipid droplet formation (EC50 = 0.41 and 0.92 μmol·L−1, respectively) and lower triglyceride levels by 50%&n...
Source: Chinese Journal of Natural Medicines - Category: Complementary Medicine Source Type: research
Authors: Health Promotion and Chronic Disease Prevention in Canada editorial staff Abstract This corrigendum is being published to correct a number of errors and imprecisions, on pages 437-442, of the following article:Rao DP, Patel P, Roberts KC, Thompson W. Obesity and healthy aging: social, functional and mental well-being among older Canadians. Health Promot Chronic Dis Prev Can. 2018;38(12):437-44. doi: 10.24095/hpcdp.38.12.01. PMID: 31517470 [PubMed - in process]
Source: Health Promotion and Chronic Disease Prevention in Canada - Category: International Medicine & Public Health Tags: Health Promot Chronic Dis Prev Can Source Type: research
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