Pregnancy outcome in foetuses with increased nuchal translucency - 10-years' experience in a prenatal medical practice.

This study describes pregnancy outcome of a population of foetuses with increased NT that were examined in a medical practice by a single observer over a period of 10 years with state of the art ultrasound equipment. We observed a relatively large proportion of foetuses with abnormal karyotype. In euploid foetuses, increased NT was associated with a wide range of foetal malformations and genetic syndromes. What are the implications of these findings for clinical practice and/or further research? Even mildly increased NT thickness is associated with an adverse pregnancy outcome, underlining the importance of thorough ultrasound examinations. Specialised prenatal medical practices can provide state-of the art technology and provide improve parental counselling. PMID: 31416379 [PubMed - as supplied by publisher]
Source: Journal of Obstetrics and Gynaecology - Category: OBGYN Tags: J Obstet Gynaecol Source Type: research

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Conclusion: In healthy pregnancy, we reported CIMT was related to BMI and maternal age but not parity or gestational age. PMID: 31535936 [PubMed - as supplied by publisher]
Source: Hypertension in Pregnancy - Category: OBGYN Tags: Hypertens Pregnancy Source Type: research
Authors: Leite DFB, Cecatti JG Abstract The actual burden and future burden of the small-for-gestational-age (SGA) babies turn their screening in pregnancy a question of major concern for clinicians and policymakers. Half of stillbirths are due to growth restriction in utero, and possibly, a quarter of livebirths of low- and middle-income countries are SGA. Growing body of evidence shows their higher risk of adverse outcomes at any period of life, including increased rates of neurologic delay, noncommunicable chronic diseases (central obesity and metabolic syndrome), and mortality. Although there is no consensus re...
Source: The Scientific World Journal - Category: Science Tags: ScientificWorldJournal Source Type: research
Publication date: Available online 24 July 2019Source: Reproductive BioMedicine OnlineAuthor(s): S.A. Neal, S.J. Morin, M.D. Werner, N.A. Gueye, P. Pirtea, R.T. Scott, L.R. GoodmanAbstractResearch questionIs T-shaped uterine cavity morphology associated with adverse pregnancy outcomes after transfer of a single thawed euploid blastocyst?DesignIn this secondary analysis of a prospective cohort study, 648 patients with three-dimensional ultrasound (3D-US) data obtained on the day before embryo transfer were categorized into three groups according to uterine cavity morphology: normal (n = 472), intermediate (n = 166) ...
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
ConclusionsIntrauterine Bigatti Shaver® is a feasible technique for placental remnants removal. Further studies comparing various surgical treatment are needed to define which technique is the safest and completely remove placental remnants.
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
Pregnant women who are at risk of preterm birth are often stressed, anxious and depressed because of worries and fears related to the health of the unborn baby, their own health and uncertainty about the futur...
Source: BMC Pregnancy and Childbirth - Category: OBGYN Authors: Tags: Research article Source Type: research
In this study, we aimed to identify and determine the efficacy of serum biomarkers for the prompt diagnosis of ectopic pregnancy. For this purpose, the serum concentrations of progesterone, β human chorionic gonadotropin (β‑hCG) and cancer antigen‑125 (CA125) were detected by solid‑phase, competitive binding chemiluminescent enzyme immunoassays. Flow cytometry was used to analyze the percentage of CD3+ T cells in women with ectopic pregnancy. Pathological analysis of tubal and villus tissues was performed by hematoxylin and eosin (H&E) staining. After receiving an injection of methotrexate (MTX), patie...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Conclusion Although TVS is useful for screening for induction failure, this tool should not be used as an indication for cesarean section.Resumo Objetivo Nem sempre a indu ção do parto termina emparto vaginal, expondo tanto a mãe quanto o feto aos riscos inerentes ao procedimento de indução, ou a uma possível cesárea. A ultrassonografia transvaginal (UTV) semostrou interessante instrumento na predição da prematuridade e, neste estudo, utilizamos este instrume nto na situação inversa: indução do parto no pós-datismo. Mét...
Source: Revista Brasileira de Ginecologia e Obstetricia - Category: OBGYN Source Type: research
The aim of the current study was to examine whether there was an association between maternal adiposity and fetal kidney growth in late gestation (>28  weeks) and kidney function in infants,28  weeks) and kidney function in infants,28  weeks gestation by bioelectrical impedance analysis. Fetal kidney structure was assessed by ultrasound. Renal function indicators (urinary albumin:creatinine and protein:creatinine) were measured in infants from a spot urine collection from nappies. Multiple linear regression and multi‐level mix ed effects linear regression models with clustering were used to account for ...
Source: Physiological Reports - Category: Physiology Authors: Tags: Original Research Source Type: research
X-linked hydrocephalus (XLH), a genetic disorder, has an incidence of 1/30,000 male births. The great proportion of XLH is ascribed to loss-of-function mutations of L1 cell adhesion molecule gene (L1CAM), but silent mutations in L1CAM with pathogenic potential were rare and were usually ignored especially in whole-exome sequencing (WES) detection. In the present study, we describe a novel silent L1CAM mutation in a Chinese pregnant woman reporting continuous five times pregnancies with fetal hydrocephalus. After fetal blood sampling, we found c.453G> T (p.Gly151 = ) in the L1CAM gene of the fetus by WES; RT-PCR of the m...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
While the incidence of falls has been described to increase with pregnancy, the mechanism behind this is unclear. Pregnancy associated changes in lower extremity muscle strength could be a possible factor influencing injury risk. Thus, the aim of this longitudinal study was to investigate muscle strength and architectural properties of the lower limbs in different stages of pregnancy and postpartum. In nineteen pregnant women (30 ± 4 years) and fifteen non-pregnant controls (28 ± 4 years) muscle strength and architectural properties of the vastus lateralis muscle were assessed combining dynamometry, ultrasoun...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
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