Restoration of rostral cerebrospinal fluid flow to solve treatment failure caused by obstruction in long-term intrathecal baclofen administration.

Conclusion: Preliminary results showed that the restoration of rostral CSF flow might result in an effective ITB treatment in patients with an intrathecal obstruction. PMID: 31418647 [PubMed - as supplied by publisher]
Source: Journal of Spinal Cord Medicine - Category: Orthopaedics Tags: J Spinal Cord Med Source Type: research

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Neuropathic pain causes severe suffering, and most patients are resistant to current therapies. A core element of neuropathic pain is the loss of inhibitory tone in the spinal cord. Previous studies have shown that foetal GABAergic neuron precursors can provide relief from pain. However, the source of these precursor cells and their multipotent status make them unsuitable for therapeutic use. Here, we extend these findings by showing, for the first time, that spinally transplanted, terminally differentiated human induced pluripotent stem cell-derived GABAergic (iGABAergic) neurons provide significant, long-term, and safe r...
Source: Pain - Category: Anesthesiology Tags: Research Paper Source Type: research
Publication date: February 2020Source: The Lancet Neurology, Volume 19, Issue 2Author(s): Annemie Heselmans
Source: The Lancet Neurology - Category: Neurology Source Type: research
Spinal Cord, Published online: 22 January 2020; doi:10.1038/s41393-020-0422-xCo-development of a physiotherapist-delivered physical activity intervention for adults with spinal cord injury
Source: Spinal Cord - Category: Research Authors: Source Type: research
CONCLUSIONS: The up-regulation of miR-7a alleviated the injury-induced oxidative stress and inhibited apoptosis by down-regulating NF-κB pathway in SCI rats. PMID: 31957813 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
This study aims to provide a holistic summary of the global scientific outputs about Spinal Cord Injury through bibliometr...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
Populations with reduced sensory and motor function, such as spinal cord injury (SCI) are at increased risk of depression, anxiety, pain, and poorer quality of life (QoL). Mindfulness-Based Interventions (MBIs...
Source: BMC Neurology - Category: Neurology Authors: Tags: Research article Source Type: research
Conclusion: The Hindi version of the SCIM III is easy and understandable to the large Hindi speaking Indian population.
Source: Annals of Indian Academy of Neurology - Category: Neurology Authors: Source Type: research
DISCUSSION: Serious problems in environmental barriers, medical care and labor market participation were identified for people with SCI. The results will be reported to and discussed with political decision makers and further actors to create solutions. This requires extensive efforts, like modification in building law and home support. PMID: 31962349 [PubMed - as supplied by publisher]
Source: Die Rehabilitation - Category: Rehabilitation Authors: Tags: Rehabilitation (Stuttg) Source Type: research
Condition:   Spinal Cord Injuries Intervention:   Other: Assessment Sponsor:   İstinye University Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Myelin is the sheathing of nerves, essential to their function. Excessive loss produces disabling and ultimately fatal conditions such as multiple sclerosis, but we all lose myelin integrity to some degree as a consequence of the damage and dysfunction of degenerative aging. This most likely contributes to cognitive decline and other age-related issues. A number of different approaches have been identified to boost the operation of the normal maintainance processes that remyelinate nerves, such as FGF21 upregulation, or increasing the size of remyelinating cell populations. Here, researchers discover another possible trigg...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
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