Histogenetic Guidelines to Perform Sentinel Lymph Node Biopsy in T1b Melanomas of the 8th Edition American Joint Committee on Cancer

In comparison with the 7th Edition, the 8th Edition of the American Joint Committee on Cancer (AJCC) staging system for melanoma no longer considers the mitotic count in the a or b T1 categorization, but it adopts a sub-stratification based on Breslow depth: T1a ≤ 0.8 mm without ulceration and T1b ≤ 0.8 mm with ulceration or 0.8 to 1 mm with or without ulceration. Skin melanoma can be subdivided by Breslow depth into thin melanoma (≤1 mm) or thick melanoma (>1  mm). According to the AJCC 8th Edition, a and b specifications are assigned based on ulceration and depth, which replace the mitotic count for square millimeter.
Source: Journal of the American College of Surgeons - Category: Surgery Authors: Tags: Letter Source Type: research

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We present a 48-year-old woman affected by metastatic uveal melanoma treated with nivolumab (3 mg/kg every 2 weeks). The patient had no previous history of autoimmune disease or dermatologic conditions. At the fourth month of treatment, on cutaneous examination, she presented multiple whitish vitiligo-like patches on the trunk, axillae, hands and face. Diagnosis of melanoma-associated leukoderma vitiliginous reaction was made. Over the following months, the melanoma-associated leukoderma lesions slowly progressed with cigarette paper-like appearance and indurated texture. A skin biopsy leaded the diagnosis of extragenital ...
Source: Anti-Cancer Drugs - Category: Cancer & Oncology Tags: Case Reports Source Type: research
Sentinel lymph node (SLN) biopsy is currently a valuable and reliable diagnostic procedure for precise staging of malignant melanoma (MM) patients. We assessed whether the genetic testing in SLNs from MM patients can be an independent prognostic factor. A retrospective study analysis was conducted for 35 patients (ratio of men to women, 17:18) who underwent SLN biopsy and primary cutaneous melanoma excision in our institution from January 2013 to June 2018. The median patient age was 71 years (range, 13-83 years).
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Melanoma and Other Skin Cancers Source Type: research
The incidence of Merkel cell carcinoma (MCC), a rare and highly metastatic skin malignancy, has sharply increased in the last decade. Clinical biomarkers are urgently needed for MCC prognosis, treatment response monitoring, and early diagnosis of relapse. The clinical interest of circulating tumors cells (CTCs) has been validated in many solid cancers. The aim of this study was to compare CTC detection and characterization in blood samples of patients with MCC using the CellSearch ® System and the RosetteSep™ -DEPArray™ workflow, an innovative procedure to enrich, detect and isolate single CTCs.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Melanoma and Other Skin Cancers Source Type: research
Melanoma is a malignant neoplasm originating from pigment producing skin cells known as melanocytes. It is the most fatal among the cutaneous carcinomas. Despite being more commonly encountered in Western countries among Caucasian populations, Southeast Asian countries, including the Philippines, have a subset population affected with the disease. In this retrospective study, a chart and slide review of all the recorded melanoma cases in the Philippine General Hospital from 2010 until 2017 was done.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Melanoma and Other Skin Cancers Source Type: research
Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer after basal cell carcinoma. While most cases are cured by excision, a substantial number of patients will develop local, regional, or distant recurrences, with the number of cSCC-related deaths approaching that from melanoma. Several clinical decisions, including the extent of surgical margins, the use of adjuvant radiation or chemotherapy, and sentinel lymph node biopsy/completion dissection, could be informed by a patient ’s relative risk of recurrence.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
Introduction: Total body photography (TBP) is a screening tool shown to enhance melanoma detection and reduce benign nevus biopsies. Such practices are usually limited to individuals with a personal or family history of atypical nevi, melanoma, or nonmelanoma skin cancers. Melanoma depth is the most important prognostic indicator of mortality and early detection improves survival. We previously demonstrated that computer-assisted serial comparison of TBP images can yield small malignant lesions which may be in their initial growth phase.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
Background: Melanoma is the most common skin cancer in patients under 20 years. Staging procedures typically follow those in adults; however little is known about utilization of sentinel lymph node biopsy (SLNB) and predictors of positive sentinel nodes. We aimed to assess SLNB utilization and factors affecting SLN positivity in a pediatric melanoma cohort.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
Over 5.4 million cases of non-melanoma skin cancer (NMSC) arise yearly, primarily in the elderly. In older patients with comorbidities, long-term benefits of treatment must be balanced with short-term risks. As limited life expectancy and Charlson comorbidity index have not been shown to affect treatment decisions, our study aimed to identify specific clinical characteristics differentiating untreated and treated patients among the elderly. We performed a retrospective cross-sectional review of biopsy-proven skin cancers between January 2017 and January 2018 at a single academic center.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Epidemiology Source Type: research
Journal of Innovative Optical Health Sciences,Volume 12, Issue 04, July 2019. Melanoma, characterized by high mortality, rapid development and accompanied with angiogenesis is the most typical malignant tumor in skin cancer. Hence, the detection of blood vessels is of much significance. The early vascular network has small scale. If we remove the tumor early and biopsy it, it will increase the spread of the cancer cells and infection and bleeding. In this case, we presented a new angiography method. A high-resolution OCT system for noninvasive angiographic imaging of early skin melanoma  — Swept Source Optical C...
Source: Journal of Innovative Optical Health Sciences - Category: Biomedical Science Authors: Source Type: research
Authors: de Menezes SL, Kelly JW, Wolfe R, Farrugia H, Mar VJ Abstract OBJECTIVE: To assess changes in the choice of skin biopsy technique for assessing invasive melanoma in Victoria, and to examine the impact of partial biopsy technique on the accuracy of tumour microstaging. DESIGN: Retrospective cross-sectional review of Victorian Cancer Registry data on invasive melanoma histologically diagnosed in Victoria during 2005, 2010, and 2015. SETTING, PARTICIPANTS: 400 patients randomly selected from each of the three years, stratified by final tumour thickness: 200 patients with thin melanoma ( 4.0 ...
Source: Medical Journal of Australia - Category: General Medicine Tags: Med J Aust Source Type: research
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