Evaluating the Lipid-Lowering Effects of α-lipoic Acid Supplementation: A Systematic Review.

Evaluating the Lipid-Lowering Effects of α-lipoic Acid Supplementation: A Systematic Review. J Diet Suppl. 2019 Aug 15;:1-15 Authors: Erickson N, Zafron M, Harding SV, Marinangeli CPF, Rideout TC Abstract Dietary supplementation of α-lipoic acid, an 8-carbon organosulfur compound, has been widely reported to lower blood glucose concentration and/or improve insulin sensitivity in previous randomized controlled trials. Although animal model studies further report fairly consistent lipid lowering in both blood and tissue pools in response to α-lipoic acid supplementation, results from human studies are mixed. According to PRISMA guidelines, we conducted a systematic review of published randomized controlled studies (RCTs) to assess the efficacy of α-lipoic acid supplementation as a strategy to improve dyslipidemia, with a focus on serum lipid endpoints including TC, low density lipoprotein cholesterol (LDL-C), HDL-C, and TG. PubMed, EMBASE, Cochrane Evidence-Based Medicine Reviews, Proquest, Web of Science, and Scopus were searched to identify RCTs that reported the effects of α-lipoic acid on blood lipid concentrations from 1970 to 2017. We included RCTs reporting blood lipid responses in adults supplemented with oral α-lipoic acid versus a placebo or control for at least one month. Studies were reviewed and data were extracted by two independent study authors. Seventeen studies were deemed eligible for inclusion. Overall, mean p...
Source: Journal of Dietary Supplements - Category: Nutrition Tags: J Diet Suppl Source Type: research