Proteomic analysis of synovial fluid identifies periostin as a biomarker for anterior cruciate ligament injury

Emerging evidence suggests that injury to the anterior cruciate ligament (ACL) typically initiates biological changes that contribute to the development of osteoarthritis (OA). The molecular biomarkers or mediators of these biological events remain unknown. The goal of this exploratory study was to identify novel synovial fluid biomarkers associated with early biological changes following ACL injury distinct from findings in end-stage OA.

Source: Osteoarthritis and Cartilage - August 16, 2019 Category: Rheumatology Authors: Robert H. Brophy, Lei Cai, Xin Duan, Qiang Zhang, R. Reid Townsend, Ryan Nunley, Farshid Guilak, Muhammad Farooq Rai Source Type: research