Individualising therapy for drug-sensitive tuberculosis
Publication date: Available online 16 August 2019Source: The Lancet Respiratory MedicineAuthor(s): Hanif Esmail, Marc C Lipman, Andrew Nunn, Timothy M Walker
Trends in Elevated Blood Lead Levels Using 5 and 10 µg/dL Levels of Concern Among Refugee Children Resettled in Massachusetts, 1998-2015. Public Health Rep. 2019 Sep 20;:33354919874078 Authors: Geltman PL, Smock L, Cochran J Abstract OBJECTIVES: Refugee children are known to have a high prevalence of elevated blood lead levels (EBLLs). We sought to determine trends in EBLLs among refugee children during an 18-year period and examine relationships between descriptive characteristics and EBLLs by using 10 µg/dL and 5 µg/dL levels of concern. METHODS: We retrospectively evaluated ref...
CONCLUSIONS: Our findings indicate that persons experiencing homelessness bear an undue burden of tuberculosis mortality in Texas. The burden may be related to poorer health caused by poverty stressors, comorbidities, or lack of access to health care. PMID: 31539480 [PubMed - as supplied by publisher]
We report 1 known false-negative, in a patient who developed disseminated TB on anti-TNF therapy. Indeterminate testing rates were higher at IBD diagnosis than during treatment (10.3% vs 5.3%, P
Conclusions: Anthropometric, genetic, and dosage characteristics of Mexican patients with TB are an important source of risk for subtherapeutic plasma concentrations of anti-TB drugs. Factors such as lower-than-recommended RMP dose, male patients with TB, and MDR1 3435 genotype, in addition to age group, body mass index, and INH acetylator phenotype based on NAT2 genotype, should be considered during treatment.
Conclusion: Our study first implied that the A variant of rs17687727 in TGFBRAP1 influenced the susceptibility to ATDILI in first-line antituberculosis combination treatment in the Han Chinese population in a dependent manner. PMID: 31534460 [PubMed]
Molecules, Vol. 24, Pages 3433: Investigation of 5’-Norcarbocyclic Nucleoside Analogues as Antiprotozoal and Antibacterial Agents Molecules doi: 10.3390/molecules24193433 Authors: Anastasia L. Khandazhinskaya Elena S. Matyugina Pavel N. Solyev Maggie Wilkinson Karen W. Buckheit Robert W. Buckheit Larisa N. Chernousova Tatiana G. Smirnova Sofya N. Andreevskaya Khalid J. Alzahrani Manal J. Natto Sergey N. Kochetkov Harry P. de Koning Katherine L. Seley-Radtke Carbocyclic nucleosides have long played a role in antiviral, antiparasitic, and antibacterial therapies. Recent results from ou...
We report the case of a 10-year-old child treated for latent tuberculosis infection (LTBI) with pyrazinamide (PZA) and levofloxacin after contact with a smear-positive multidrug-resistant tuberculosis adult. Over the course of the treatment, the patient developed a drug-induced fulminant hepatitis attributed to the combination of PZA and levofloxacin. This case highlights the hepatotoxicity of the association of second-line anti-TB treatment in children.
Background: The incidence of drug-resistant forms of tuberculosis (DR-TB) and the number of children treated with second-line drugs (SLDs) are increasing. However, limited amount of information is available regarding the use of SLDs in this population. Methods: To describe the treatment of pediatric TB with SLDs and factors associated with use of SLDs in children with and without documented DR-TB, records of pediatric TB patients referred to a center in Italy from 2007 to 2018 were reviewed retrospectively. Results: Of 204 children diagnosed with active TB during the study period, 42 were treated with SLDs because ...
This retrospective study investigated outcomes among lost to follow-up (LTFU) adolescents and young adults (AYAs: 10–24 years of age) with tuberculosis (TB) registered from 2008 to 2014 in Gaborone, using surveillance data. Of 68 LTFU AYAs, 16 repeated treatment; 8 completed and 6 were again LTFU. Of 4 confirmed deaths, 3 had TB/HIV coinfection. Approaches to improve AYA retention in TB care are needed.
Conclusions: The effectiveness of TB management was acceptable. Our routine procedures for the exclusion of TBI appear safe.