High efficacy of hypofractionated proton therapy with 4 fractions of 5  Gy as a boost to 50 Gy photon therapy for localized prostate cancer

Technical advances have made it possible to create highly conformal dose distributions using photon-based radiotherapy, prompting interest in hypofractionated radiotherapy. Prostate cancer shows higher fractionation sensitivity and a lower α/β ratio than healthy tissue; thus, the rationale is to use higher doses per fraction compared with conventional fractionation [1–3]. Randomized studies have shown that moderate hypofractionation was not inferior to conventional fractions [4–6], but they have not demonstrated the concept of b iological dose escalation i.e.
Source: Radiotherapy and Oncology - Category: Radiology Authors: Tags: Original Article Source Type: research