Bayesian reconstruction of a vancomycin-resistant Enterococcus transmission route using epidemiologic data and genomic variants from whole genome sequencing
ConclusionA Bayesian approach for transmission route reconstruction using epidemiologic data and genomic variants from WGS can be applied in actual VRE outbreaks. This may contribute to the design and implementation of effective infection control measures.
AbstractEarly in its evolution,Enterococcus faecium acquired traits that allowed it to become a successful nosocomial pathogen.E. faecium inherent tenacity to build resistance to antibiotics and environmental stressors that allows the species to thrive in hospital environments. The continual wide use of antibiotics in medicine has been an important driver in the evolution ofE. faecium becoming a highly proficient hospital pathogen.For successful prevention and reduction of nosocomial infections with vancomycin resistantE. faecium (VREfm), it is essential to focus on reducing VREfm carriage and spread. The aim of this revie...
Publication date: August 2020Source: American Journal of Infection Control, Volume 48, Issue 8, SupplementAuthor(s): Michal Stachura, Marie-Astrid Lefebvre
Publication date: August 2020Source: Journal of Hospital Infection, Volume 105, Issue 4Author(s): S.A. Egan, S. Corcoran, H. McDermott, M. Fitzpatrick, A. Hoyne, O. McCormack, A. Cullen, G.I. Brennan, B. O'Connell, D.C. Coleman
ConclusionThis study revealed an increase in ST117 strains from 2008 to 2018, accompanied by a shift toward CT71 strains with thevanB genotype in 2018. We did not detect resistance or virulence traits in CT71 that could confer survival advantage compared to other CTs among ST117 strains. To date, it is not clear why ST117 and in particular strain type ST117 CT71 predominates over other strains.
ConclusionOur study highlights the importance of screening implementation in a NICU setting since this outbreak could have been prevented by active screening of all out-born transfer patients and by having adopted mandatory screening into the NICU ’s routine procedures. Screening for multi-drug resistant organisms upon admission of all transferred patients to the NICU has been implemented.
Publication date: Available online 19 May 2020Source: Journal of Hospital InfectionAuthor(s): S.A. Egan, S. Corcoran, H. McDermott, M. Fitzpatrick, A. Hoyne, O. McCormack, A. Cullen, G.I. Brennan, B. O’Connell, D.C. Coleman
CONCLUSION: The increasing annual number of eXDR notifications and eXDR strains received by the NRC is multifactorial but reflects a worrying spread of eXDR in France. The number of infections remains low, but this article shows that existing recommendations are not fully implemented. PMID: 32113869 [PubMed - as supplied by publisher]
Abstract Nosocomial infections remain a serious public health problem with serious consequences. Hospital hygiene surveys are a basic tool in the surveillance and control of nosocomial infections. These surveys are also a tool for raising the awareness and information of the nursing staff. The nosocomial infection control committee was asked to carry out an epidemiological survey within a general surgery department following a nosocomial infection outbreak. During this survey, 100 samples taken from surfaces, small equipment and medical devices were collected. The results showed that 80 samples (80%) were positive...
In the context of an aging population, identifying risk factors for Vancomycin-resistant enterococci (VRE), specific to older people, is important. However, if age is a known risk factor for VRE infection, a l...
DiscussionRoutine hygienic maintenance of the PTS makes pathogen transmission by PTS highly unlikely, although entry racks should be regularly disinfected. Any involvement of the PTS in our VRE outbreak was also unlikely.