A study on the cross-resistance character of isoniazid, para-aminosalicylic acid and pasiniazid against isoniazid resistant Mycobacterium tuberculosis in China
ConclusionsTaken together, our results demonstrated that PAS resistance and mutations in katG, inhA promoter or oxyR-ahpC intergenic region in INH resistant M. tuberculosis has little effect on pasiniazid susceptibility.
“This strain of tuberculosis (TB) is XDR-TB – extremely drug resistant tuberculosis– and is, as the name implies, highly resistant to the standard treatments,” says professor and TB/HIV expert Jason Farley, PhD, MPH, ANP-BC, AACRN, FAAN. HIV weakens the immune system, increasing the risk of TB in people with HIV. Dr. Farley’s Center, The REACH The post There’s a new cure for the deadliest strain of tuberculosis. So what’s that mean for the REACH Initiative’s HIV research in South Africa? appeared first on Johns Hopkins Nursing Magazine.
ConclusionsResistance to isoniazid and rifampicin was observed at levels similar to those published nationwide, with rates of multi-resistance being somewhat lower. Rates of HIV-tuberculosis co-infection have decreased considerably.
ConclusionThese results may be of value in rapid molecular detection of MDR- and XDR-TB isolates in clinical samples in Hebei Province.
Conclusion: The revelaed different NTM species, with predominance ofM.simiaeand various AMR profiles provide a current epidemiologic database and help guiding the selection of appropriate empirical therapy once the clinical relevance is established.
Many pathogens that caused devastating disease throughout human history, such as Yersinia pestis, Mycobacterium tuberculosis, and Mycobacterium leprae, remain problematic today. Historical bacterial genomes represent a unique source of genetic information and advancements in sequencing technologies have allowed unprecedented insights from this previously understudied resource. This minireview brings together example studies which have utilized ancient DNA, individual historical isolates (both extant and dead) and collections of historical isolates. The studies span human history and highlight the contribution that sequenci...
ConclusionsIn recent years, we identified a low incidence of DR-TB as well as the poor outcome of DR-TB treatment. The majority of cases were primary drug-resistant and foreign-born. To further improve treatment outcome, special attention should be given to the high-risk DR-TB patients.
ConclusionsAlthough the introduction of a new pathway has decreased the administrative burden when accessing unregistered antimicrobials, this study highlights the range of clinical conditions for which there are no registered drugs available in Australia.What is known about the topic?With increasing antimicrobial resistance and a paucity of novel antimicrobials entering the market, access to older, previously less-used antimicrobials is increasingly important in clinical practice. Accessing unregistered antimicrobials is common practice in Australian hospitals, but the range of clinical indications for which they are used...
ConclusionSynergistic and additive effects between these two drugs combinations offers an attractive chemotherapeutic regimens against all drug resistant clinical isolates.
ConclusionPreoperative diagnosis of tuberculous abdominal cocoon is a true challenge. Early diagnostic peritoneal biopsy should be recommended and surgery is usually unnecessary if definitive diagnosis can be made.