Inhibitory activity of Scorzonera latifolia and its components on enzymes connected with healing process

Publication date: Available online 17 August 2019Source: Journal of EthnopharmacologyAuthor(s): Esra Küpeli Akkol, Karel Šmejkal, Ekin Kurtul, Mert Ilhan, Fatma Tuğçe Güragac, Gülçin Saltan Çitoğlu, Özlem Bahadır Acıkara, Josef Cvačka, Miloš BuděšínskýAbstractEthnopharmacological relevanceScorzonera latifolia (Fisch. &Mey.) DC. (Asteraceae)grows naturally in Eastern Anatolia, northeastern Iran, and Caucasus. Latex of S. latifolia roots is used in Turkish folk medicine for its analgesic effects, externally to cure infertility in women, and internally as an antihelmintic. The milk obtained from the stem of the Scorzonera species is used for wound healing activity. Antinociceptive, anti-inflammatory, wound-healing, antioxidant, and antimicrobial activities have previously been reported for S. latifolia.Aim of the study: A methanol extract of the aerial parts of Scorzonera latifolia (Fisch. &Mey.) DC. that had been shown to possess wound-healing activity, was used to elucidate the possible mechanism of the wound-healing activity and to identify the compound(s) responsible for the effect by means of bioassay-guided fractionation.Materials and methodsThe wound-healing activity potential of methanol extract of S. latifolia was detected by evaluating the inhibitory activity on the collagenase, hyaluronidase and elastase, which play important roles in the wound-healing process. Succesive fraction...
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research

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ConclusionThis simple tool appears to accurately predict the likelihood of a live birth for a patient undergoing ART after surgery for endometriosis-related infertility. It could be used to counsel patients in their choice between spontaneous versus ART conception, or oocyte donation.
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
Publication date: Available online 21 September 2019Source: European Journal of Obstetrics &Gynecology and Reproductive BiologyAuthor(s): Luis Alonso Pacheco, Antonio Simone Laganà, Simone Garzon, Arantxa Perez Garrido, Alberto Flores Gornes, Fabio GhezziABSTRACTObjectiveTo evaluate the effectiveness of hysteroscopic outpatient metroplasty in women with T-shaped uterus and primary reproductive failure.Study DesignProspective cohort study including nulliparous women with primary unexplained infertility, repeated in vitro fertilization (IVF) failure or recurrent spontaneous miscarriage and T-shaped uterus anomaly ...
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
Publication date: Available online 21 September 2019Source: Journal of Pharmaceutical and Biomedical AnalysisAuthor(s): Yamei Xu, Hongmei Lu, Yang Wang, Zhimin Zhang, Wu QianAbstractMetabolomics measurements of seminal plasma are widely used in diagnosis and finding of molecular mechanisms of male infertility. However, so far the limitation of metabolome coverage of analytical methods hinders comprehensive metabolite biomarker finding. Moreover, the widely used case-control comparison is not enough to unveil the detailed correlations of the metabolic changes with different sperm abnormalities. In this work, we aimed to hav...
Source: Journal of Pharmaceutical and Biomedical Analysis - Category: Drugs & Pharmacology Source Type: research
This article describes a nurse-led oncofertility program that offers counseling to patients of any age, with any diagnosis, and at any stage of treatment. METHODS: An overview of the literature and a description of a clinical practice, including relevant case studies, are presented. FINDINGS: FNSs can seek to lessen the financial burden associated with family building before and after cancer treatment by developing a network of reproductive specialists who will provide discounted services and by sharing information on available resources that might reduce the costs. PMID: 31538989 [PubMed - in process]
Source: Clinical Journal of Oncology Nursing - Category: Nursing Authors: Tags: Clin J Oncol Nurs Source Type: research
Patients do IVF with a lot of hope, because they know this is the one method which maximizes their chances of getting pregnant. They pin all their hopes on the IVF cycle, but when the IVF cycle fails, they are completely heartbroken , and worry about whether they'll ever be able to get pregnant at all.However, do remember that patients do get pregnant even after a failed IVF cycle in their bedroom. The chances of this happening depends on the reason for the infertility.Of course, if you have blocked tubes , or the reason for your infertility is azoospermia, then you're not going to get pregnant on your own.But if your...
Source: Dr.Malpani's Blog - Category: Reproduction Medicine Source Type: blogs
Authors: Jurkowska K, Kratz EM, Sawicka E, Piwowar A Abstract In the XXIst century in highly developed countries, progressively decreasing male reproductive potential is indicated. In recent years epidemiological studies indicate the deterioration of semen parameters: reduction of ejaculate volume, sperm count, and mobility, as well as abnormalities in their morphology. Male infertility can result from many different agents, such as: anatomical or genetic abnormalities, systemic or neurological diseases, infections, trauma, iatrogenic injury, gonadotoxins and development of sperm antibodies and lifestyle (especiall...
Source: Journal of Physiology and Pharmacology - Category: Drugs & Pharmacology Tags: J Physiol Pharmacol Source Type: research
Publication date: Available online 19 September 2019Source: PathophysiologyAuthor(s): Olugbemi T Olaniyan, Adebayo Femi, Gambo Iliya, Dare Ayobami, Elvis Godam, Eweoya Olugbenga, Okoli Bamidele, Pratap Chand MaliAbstractBackgroundPolycystic ovary syndrome (PCOS), also known as the Stein-Leventhal syndrome is one of the most common causes of anovulation, infertility and hyperandrogenism in women, affecting between 5 - 10 % of women of reproductive age (12 – 35 years) worldwide. Despite substantial effort to define the cause of PCOS, its pathophysiology remains poorly understood. Consequently, determining the mechanism...
Source: Pathophysiology - Category: Pathology Source Type: research
The objective is to create a nomogram to predict the likelihood of a live birth after surgery followed by assisted reproductive technology (ART) for patients with endometriosis-related infertility.
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - Category: OBGYN Authors: Tags: Full length article Source Type: research
ConclusionIn women with endometrial polyps, the prevalence of CE in infertile women is higher than that in fertile women. Pregnancy outcome in infertile women with treated CE was similar to those who were infertile and without CE.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
Ericka Boone, Ph.D., Director of NIH Division of Loan Repayment  Applications are currently being accepted for the FY 2020 NIH Loan Repayment Program (LRP) until November 15, 2020. And, there are some important changes to the program we would like to spotlight for you. For over three decades, the NIH LRPs have helped recruit and retain highly qualified health professionals into biomedical or biobehavioral research careers. LRP award funds repay a recipient’s qualified educational debt in return for a commitment to engage in NIH mission-relevant research at a domestic, nonprofit, or government entity. Pri...
Source: NIH Extramural Nexus - Category: Research Authors: Tags: blog Open Mike biomedical research workforce loan repayment program Source Type: funding
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