Serum active 1,25(OH)2D, but not inactive 25(OH)D vitamin D levels are associated with cardiometabolic and cardiovascular disease in psoriasis

Vitamin D exists as an inactive 25-hydroxyvitamin D (25(OH)D) in the bloodstream, which is converted to active 1,25-dihydroxyvitaminD (1,25(OH)2D) in target tissues. Cohort studies reporting cardiovascular disease among individuals with low vitamin D are inconsistent and solely measure 25(OH)D. Psoriasis, a chronic inflammatory disease, is a vitamin D deficient state and is associated with increased cardiovascular disease risk. While serum 25(OH)D is routinely measured, we hypothesized that measurement of 1,25(OH)2D in psoriasis may perform better than 25(OH)D in capturing cardiovascular risk.

Source: Atherosclerosis - August 16, 2019 Category: Cardiology Authors: Martin P. Playford, Amit K. Dey, Claudia Zierold, Aditya A. Joshi, Frank Blocki, Fabrizio Bonelli, Justin A. Rodante, Charlotte L. Harrington, Joshua P. Rivers, Youssef A. Elnabawi, Marcus Y. Chen, Mark A. Ahlman, Heather L. Teague, Nehal N. Mehta Source Type: research