Antibacterial and antifungal activity of defensins from the Australian paralysis tick, Ixodes holocyclus

This study reveals the presence of a multigene defensin family in I. holocyclus with wide antimicrobial activity.
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research

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Authors: Fukushima K, Yanagisawa N, Sekiya N, Izumiya H Abstract Non-typhoidal Salmonella (NTS) infection is a major pathogen causing gastroenteritis among immunocompetent adults. NTS infection is mainly transmitted by contaminated food and water, but some cases are transmitted by animal contact. Salmonella enterica subsp. enterica serovar Poona (S. Poona) is an NTS usually transmitted by reptiles, and cases including outbreaks of gastroenteritis have been reported previously. However, invasive infections due to this organism among immunocompetent adults are rare. We herein report a case of a 39-year-old man who wa...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Epidemiology of β-Lactamase-Producing Staphylococci and Gram Negative Bacteria as Cause of Clinical Bovine Mastitis in Tunisia. Biomed Res Int. 2019;2019:2165316 Authors: Klibi A, Jouini A, Boubaker El Andolsi R, Kmiha S, Ben Hamda C, Ghedira K, Hamrouni S, Ghram A, Maaroufi A Abstract The aim of this study was to determine the species distribution of Staphylococcus, Gram negative bacteria (GNB) and the occurrence of Methicillin Resistant Staphylococci (MRS) and Extended-Spectrum β-lactamase- (ESBL-) producing GNB. Bacterial culture of 300 clinical mastitis milk samples from 30 different far...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Publication date: Available online 19 September 2019Source: Protein Expression and PurificationAuthor(s): Yi He, Yong Chen, Daniel L. Morris, Duck-Yeon Lee, Nico TjandraAbstractBax is a pro-apoptosis protein that translocates from the cytosol to the mitochondrial membrane upon initiation of programed cell death. Bax subsequently disrupts the mitochondria membrane, resulting in the release of cytochrome C which activates the downstream caspases. The structure of inactive Bax has been solved, but despite intensive investigation, the mechanism by which it regulates apoptosis is not established. The low yield of Bax expression...
Source: Protein Expression and Purification - Category: Biochemistry Source Type: research
Millions of people from Sydney to Manila, Dhaka to London and New York are marching for urgent action on climate breakdownWhy the Guardian is changing its environment languageHow you can get involved |Are you taking part in today ’s protests?Please support the Guardian ’s independent journalism1.52amBSTFor the past 24 hours, the Guardian has been reporting in real time as millions of people joined in a worldwide, youth-led climate strike – with correspondents filing dispatches from the demonstrations across the globe.Related:Across the globe, millions join biggest climate protest ever1.30amBSTThese pupper...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: School climate strikes Climate change Environment Greta Thunberg Science Global climate talks Australia news New Zealand World news Asia Pacific Fossil fuels Greenhouse gas emissions Renewable energy US news Source Type: news
In conclusion, turanose can attenuate colitis via regulatory effects on miRNA-21 expression and histone acetylation-related proinflammatory mediators. These findings also support further exploration of turanose as a potential therapeutic sugar substitute for patients with IBD.Graphical abstract
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
Publication date: Available online 19 September 2019Source: Microbial PathogenesisAuthor(s): Muhammad Altaf, Muhammad Ijaz, Awais Ghaffar, Abdul Rehman, Muhammad AvaisAbstractNon-steroidal anti-inflammatory drugs (NSAIDs) may exhibit antibacterial activity and have synergistic effects with antibiotics. One way to re-sensitize MRSA to resistant antibiotics is by combining with approved non-antibiotics. The study was intended to explore susceptibility of MRSA to various antibiotics and non-antibiotics (NSAIDs) by micro dilution broth method. MRSA isolates were confirmed by PCR (mecA gene) and in-vitro antibiotic susceptibili...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
ConclusionsIn conclusion, it would appear that the most prevalent mcr gene of E. coli from diarrheic weaned piglets in Korea was mcr-3. And, to our best knowledge, this is the first report for coexistence of two plasmid-mediated colistin resistance genes, mcr-1 and mcr-3 in the same isolates (0258, 0491, 0516) from piglets with diarrhea in Korea. Those mcr–positive isolates showed multi-drug resistance, and majority of those encoded Stx2e and F18. This indicates that the risk of inefficient treatment for edema disease in weaned piglets.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
Conclusions: Healthy children with NTS musculoskeletal infections more frequently report reptile exposure and preceding gastrointestinal symptoms and have pelvic and spinal involvement compared with children with musculoskeletal infections due to S. aureus. NTS should be considered as a potential cause of musculoskeletal infections in children with these risk factors. In contrast to previous case reports and case series, children with NTS musculoskeletal infections had a low rate of complications.
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Original Studies Source Type: research
We present a case of Candida tropicalis thyroiditis in an adolescent male with acute lymphocytic leukemia that led to disseminated candidiasis, thyroid storm and eventual total thyroidectomy for source control.
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Immunology and Host Response Source Type: research
Listeria monocytogenes meningitis in Danish children 1 month to 17 years from 2000 to 2017 was identified and patient files reviewed. There were 5 cases, equaling an annual incidence of 0.024 per 100,000 children or 0.014 when excluding 2 immunodeficient children. Even in a country with a high general incidence of listeriosis, Listeria meningitis is a rare event in healthy children.
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Brief Reports Source Type: research
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