Tissue, urine and blood metabolite signatures of chronic kidney disease in the 5/6 nephrectomy rat model

ConclusionAlthough the metabolic picture is complex, we suggest oxidative stress, the gut-kidney axis, acid –base balance, and energy metabolism as promising areas for future investigation.
Source: Metabolomics - Category: Biology Source Type: research

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CONCLUSIONS: In this population-based cross-sectional analysis, we found an association between selected PFAAs and self-reported gout. We also confirmed previous reports of an association between several PFAAs and hyperuricemia. Our study suggests that exposure to PFAAs may be a risk factor for hyperuricemia and gout. PMID: 32590180 [PubMed - indexed for MEDLINE]
Source: Chemosphere - Category: Chemistry Authors: Tags: Chemosphere Source Type: research
We describe a 42-year-old man with chronic kidney disease stage 4 who was diagnosed with a mediastinal germ cell tumor and metastases in lung and brain. Treatment with cisplatin-etoposide was considered essential for a chance of cure. In order to administer the full cisplatin dose, 4-hour hemodialysis sessions were performed after each cisplatin infusion. During treatment cycle 3, 4 and 5, total and unbound plasma platinum concentrations were measured. Trough concentrations and half-life were at the higher end of the range of those observed in patients with adequate renal function who received the same dose of cisplatin. H...
Source: Anti-Cancer Drugs - Category: Cancer & Oncology Tags: Case Reports Source Type: research
Conclusion This study indicated that chronotherapy with RAS inhibitors improved the renal damage via intrarenal RAS suppression, especially in CKD patients with an impaired renal function and nocturnal hypertension. PMID: 32938851 [PubMed - in process]
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
The original version of this article unfortunately contained a mistake.
Source: Pediatric Nephrology - Category: Urology & Nephrology Source Type: research
Source: Pediatric Nephrology - Category: Urology & Nephrology Source Type: research
AbstractCongenital nephrotic syndrome (CNS) was primarily considered one disease entity. Hence, one treatment protocol was proposed in the beginning to all CNS patients. Today, with the help of gene diagnostics, we know that CNS is a heterogeneous group of disorders and therefore, different treatment protocols are needed. The most important gene defects causing CNS areNPHS1,NPHS2,WT1,LAMB2, andPLCE1. Before active treatment, all infants with CNS died. It was stated already in the mid-1980s that intensive medical therapy followed by kidney transplantation (KTx) should be the choice of treatment for infants with severe CNS. ...
Source: Pediatric Nephrology - Category: Urology & Nephrology Source Type: research
AbstractThe global burden of chronic kidney disease (CKD) is rapidly increasing with a projection of becoming the 5th most common cause of years of life lost globally by 2040. Aggravatingly, CKD is a major cause of catastrophic health expenditure. The costs of dialysis and transplantation consume up to 3% of the annual healthcare budget in high-income countries. Crucially, however, the onset and progression of CKD are often preventable. In 2020, the World Kidney Day campaign highlights the importance of preventive interventions —be it primary, secondary, or tertiary. This complementing article focuses on outlining an...
Source: Pediatric Nephrology - Category: Urology & Nephrology Source Type: research
AbstractBackgroundAdequate calcium (Ca) intake is required for bone mineralization in children. We assessed Ca intake from diet and medications in children with CKD stages 4 –5 and on dialysis (CKD4–5D) and age-matched controls, comparing with the UK Reference Nutrient Intake (RNI) and international recommendations.MethodsThree-day prospective diet diaries were recorded in 23 children with CKD4 –5, 23 with CKD5D, and 27 controls. Doses of phosphate (P) binders and Ca supplements were recorded.ResultsMedian dietary Ca intake in CKD4 –5D was 480 (interquartile range (IQR) 300–621) vs 724 (IQR 57...
Source: Pediatric Nephrology - Category: Urology & Nephrology Source Type: research
Publication date: Available online 17 September 2020Source: Advances in Chronic Kidney DiseaseAuthor(s): Hilary Miller-Handley, Keith Luckett, Amit Govil
Source: Advances in Chronic Kidney Disease - Category: Urology & Nephrology Source Type: research
Authors: Beisland C PMID: 32930029 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Urology - Category: Urology & Nephrology Tags: Scand J Urol Source Type: research
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