Peptide dendrimers as valuable biomaterials in medical sciences

Publication date: 15 September 2019Source: Life Sciences, Volume 233Author(s): Fatemeh Sadat Tabatabaei Mirakabad, Maryam Sadat Khoramgah, Kamyar Keshavarz F., Maryam Tabarzad, Javad RanjbariAbstractPeptides are oligomers of amino acids, which have been used in a wide range of applications, particularly in medical and pharmaceutical sciences. Linear peptides have been extensively developed in various fields of medicine as therapeutics or targeting agents. The branched structure of peptide dendrimers with peptide (commonly, poly l‑Lysine) or non-peptide (commonly poly‑amidoamine) core, often exhibits valuable novel features, improves stability and enhances the functionality of peptide in comparison with small linear peptides. The potential applications of Branched and hyper-branched peptidic structures which are known as peptide dendrimers in biomedical sciences have been approved vastly. A peptide dendrimer contains three distinct parts including core, building blocks and branching units or surface functional groups. These structures provide a lot of opportunities in the pharmaceutical field, particularly for novel drug development. In this review, a brief summary of different biomedical applications of peptide dendrimers is presented, and peptide dendrimers as active pharmaceutical ingredients and drug delivery carriers are discussed. Applications of peptide dendrimers in vaccines and diagnostic tools are also presented, in brief. Generally, peptide dendrimers are promis...
Source: Life Sciences - Category: Biology Source Type: research

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HPV DNA detection in urine samples of women: "An efficacious and accurate alternative to cervical samples?" Expert Rev Anti Infect Ther. 2019 Sep 13;: Authors: Pattyn J, Van Keer S, Téblick L, Van Damme P, Vorsters A Abstract Cervical cancers are caused by persistent human papillomavirus (HPV) infections [1]. To date, HPV DNA testing using clinician-obtained cervical cells is the reference for identifying cervical infection. However, great interest has been shown for the use of self-sampling methods to detect HPV [2]. One method for self-sampling to be considered is the collection of f...
Source: Expert Review of Anti-Infective Therapy - Category: Infectious Diseases Tags: Expert Rev Anti Infect Ther Source Type: research
THE GORDON WILSON LECTURE: THE HEPATITIS C VIRUS: FROM HIPPOCRATES TO CURE. Trans Am Clin Climatol Assoc. 2019;130:104-118 Authors: Alter HJ Abstract The modern age of viral hepatitis began in the early 1960s with the serendipitous discovery of the Australia antigen, a protein that was later shown to represent the envelope of the hepatitis B virus leading to its designation as the hepatitis B surface antigen. This was the first marker for any hepatitis virus and became not only a diagnostic assay, but also a mandatory blood donor screening test and the basis for the first generation hepatitis B vaccine...
Source: Transactions of the American Clinical and Climatological Association - Category: General Medicine Tags: Trans Am Clin Climatol Assoc Source Type: research
Publication date: Available online 14 September 2019Source: Biochemical Engineering JournalAuthor(s): Xiaoxia Dai, Can Jian, Li Na, Xiaofeng Wang, Yu Dai, Dexin LiAbstractHantaan virus-like particles (VLPs) have been produced and purified by co-expressing Hantaan virus nucleocapsid (N) protein and glycoproteins (Gn and Gc) in baculovirus insect cell systems. The potential of VLPs as a vaccine was evaluated by comparing the humoral immune response and neutralizing antiserum induced by the purified VLP and the recombinant baculovirus bearing the Hantaan virus glycoproteins alone. After immunization of C57BL/6 mice, Hantaan V...
Source: Biochemical Engineering Journal - Category: Biochemistry Source Type: research
From the Karolinska Institute in Stockholm, Vincent speaks with Niklas Björkström, Ali Mirazimi, and Matti Sällberg about their work on the impact of chronic hepatitis C virus infection on NK cells, Crimean-Congo hemorrhagic fever virus vaccines, and immunotherapy to block entry of hepatitis B and D viruses. Click arrow to play Download TWiV 565 (52 MB .mp3, […]
Source: virology blog - Category: Virology Authors: Tags: This Week in Virology Crimean-Congo hemorrhagic fever virus dna vaccine hepatitis b virus hepatitis C virus hepatitis D virus immunotherapy Karolinska Institute NK cell T cell exhaustion treatment interruption viral viruses Source Type: blogs
From the Karolinska Institute in Stockholm, Vincent speaks with Niklas Björkström, Ali Mirazimi, and Matti Sällberg about their work on the impact of chronic hepatitis C virus infection on NK cells, Crimean-Congo hemorrhagic fever virus vaccines, and immunotherapy to block entry of hepatitis B and D viruses. Hosts: Vincent Racaniello Guests: Niklas Björkström, Ali Mirazimi, and Matti Sällberg Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Karolinska Huddinge CCHV experimental vaccines (J Virol) Incre...
Source: This Week in Virology - MP3 Edition - Category: Virology Authors: Source Type: podcasts
In conclusion, the agonistic anti-TLR4 mAb induces potent CD8 T-cell-dependent antitumour immunity and an inflammatory response of lesser magnitude than does LPS. The agonistic anti-TLR4 mAb has potential as an adjuvant for use in vaccines against cancer. PMID: 31515801 [PubMed - in process]
Source: Immunology - Category: Allergy & Immunology Authors: Tags: Immunology Source Type: research
Publication date: Available online 13 September 2019Source: BiologicalsAuthor(s): Alexandra Douglas-Bardsley, Catpagavalli Asokanathan, Sharon Tierney, Jason Hockley, Kevin MarkeyAbstractPertussis toxin (PT) in its detoxified form is one of the major protective antigens in vaccines against Bordetella pertussis (whooping cough). Reference preparations of native PT are required for the quality control of pertussis vaccines. Stocks of the first WHO International Standard (IS) for PT (JNIH-5) were low and a replacement was required. One candidate material was donated by a vaccine manufacturer to NIBSC. It was formulated, lyoph...
Source: Biologicals - Category: Biology Source Type: research
Publication date: Available online 14 September 2019Source: Gene Expression PatternsAuthor(s): P. Arya, P.K. Pradhan, Anutosh Paria, R. Sharma, Dev K. Verma, Ravindra, G. Rathore, N. SoodAbstractIndia is the second largest fish producing country in the world with production of 12.6 million tonnes (mt) in 2017–18, and Indian major carps (IMCs) share bulk of this fish production. Catla, Catla catla is the fastest growing species among IMCs. However, the survival rate of catla during larval rearing is normally lower than the other IMCs i.e rohu Labeo rohita, and mrigal Cirrhinus mrigala. Continuous efforts are devoted f...
Source: Gene Expression Patterns - Category: Genetics & Stem Cells Source Type: research
A woman threw a bloody menstrual cup at lawmakers and shouted, "That's for the dead babies."
Source: Washington Post: To Your Health - Category: Consumer Health News Authors: Source Type: news
Publication date: Available online 13 September 2019Source: Journal of Pharmaceutical and Biomedical AnalysisAuthor(s): Xiaochen Yin, Xin Wang, Zhigang Zhang, Yufang Li, Zhijie Lin, Huirong Pan, Ying Gu, Shaowei Li, Jun Zhang, Ningshao Xia, Qinjian Zhao
Source: Journal of Pharmaceutical and Biomedical Analysis - Category: Drugs & Pharmacology Source Type: research
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