Hybrid and hollow Poly(N,N-dimethylaminoethyl methacrylate) nanogels as stimuli-responsive carriers for controlled release of doxorubicin

Publication date: Available online 17 August 2019Source: PolymerAuthor(s): Sakineh Hajebi, Amin Abdollahi, Hossein Roghani-Mamaqani, Mehdi Salami-KalajahiAbstractSmart drug-delivery systems based on stimuli-responsive polymers are extensively studied because of their advantages in controlled release of anti-cancer drugs in response to induced stimuli. To develop a smart drug-delivery system, silica nanoparticles modified with 3-(trimethoxysilyl) propyl methacrylate (MPS) were used in inverse emulsion polymerization of N,N-dimethylaminoethyl methacrylate with N,N-methylene bisacrylamide in different amounts (MBA: 2, 4, and 8 mol%). The temperature- and pH-responsive hybrid core-shell nanoparticles were used for preparation of hollow poly(N,N-dimethylaminoethyl methacrylate) (PDMAEMA) nanogels by hydrolysis of the silica cores. Fourier-transform infrared spectroscopy was used to confirm the surface modification of silica nanoparticles with MPS. Successful synthesis of the hybrid and hollow nanogels was investigated by thermogravimetric analysis, scanning electron microscopy, and transmission electron microscopy. In addition, temperature-responsivity and phase separation behavior of the hybrid and hollow nanogels were studied by UV/Vis spectroscopy. The UV/Vis spectra showed that the absorption intensity was increased with increasing MPS and MBA contents in basic conditions. The hollow nanogels showed higher swelling/deswelling ratio compared to the hybrid nanogels in acidic m...
Source: Polymer - Category: Chemistry Source Type: research