Inhibition Effects of Some Antidepressant Drugs on Pentose Phosphate Pathway Enzymes
Publication date: Available online 16 August 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Muhammet Serhat Özaslan, Neslihan Balcı, Yeliz Demir, Mahmut Gürbüz, Ömer İrfan KüfrevioğluAbstractThe glucose metabolism in the pentose cycle is essential to the source of NADPH. Deficiency of these enzymes have been linked to depression and psychotic disorders. Depression is an increasingly prevalent mental disorder which may cause loss of labor. Antidepressant drugs are commonly employed in treatments of mood disorders and anxiety treatment. The purpose of this study is to investigate the effects of aripiprazole, mirtazapine, risperidone, escitalopram and haloperidol on the activity of 6-phosphogluconate dehydrogenase (6PGD) and glucose-6-phosphate dehydrogenase (G6PD) enzymes purified from human erythrocytes. It was found that aripiprazole, mirtazapine, risperidone, escitalopram and haloperidol show effective inhibitor properties on purified G6PD and 6PGD enzymes. The IC50 values of these drugs were found in the range of 26.03 µM-5.76 mM for 6PGD and 16.07 µM-3.85 mM for G6PD. The Ki values of the drugs were found in the range of 30.12 ± 4.07 µM-4.51 ± 1.83 mM for 6PGD and 14.21 ± 3.05 µM-4.98 ± 1.14 mM for G6PD. Usage of drugs with significant biological effects may be a hazard in some conditions.
More than 60 percent of CBD users were taking it for anxiety, according to a survey of 5,000 people. Does it help?
This study offers preliminary evidence that immune responsivity to stress induction could serve as a mechanism of treatment for mood disorders in youth, indicating a potential marker for more personalized model of healthcare.
Authors: Altaner C, Altanerova U, Jakubechova J PMID: 31608134 [PubMed]
CONCLUSION: Emerging evidence positions physicians in PMandR among the most likely to experience burnout. Although there is limited literature regarding PMandR specialists and trainees, the available evidence suggests that more than half of physicians in PMandR experience burnout. PMID: 31608964 [PubMed - as supplied by publisher]
Authors: Oderda GM, Senagore AJ, Morland K, Iqbal SU, Kugel M, Liu S, Habib AS Abstract Opioid-induced respiratory depression (OIRD) and postoperative nausea and vomiting (PONV) are challenging, resource-intensive, and costly opioid-related adverse events (ORAEs). Utilizing the Premier Healthcare Database, we identified patients> 18 years old, who underwent at least one surgical procedure of interest (i.e., cardiothoracic/vascular, general/colorectal, obstetric/gynecologic, orthopedic, or urologic), and received at least one dose of intravenous morphine, hydromorphone, or fentanyl for acute postoperative ...
CONCLUSIONS: For most mental disorders, refugees were less likely to be admitted to hospital for suicide attempt or die by suicide compared with Swedish-born individuals. Further research on risk and protective factors for suicide attempt and suicide among refugees with mental disorders is warranted. DECLARATION OF INTEREST: None. PMID: 31608856 [PubMed - as supplied by publisher]
CONCLUSIONS: Being a refugee was not an additional risk factor for suicide. Our findings regarding temporal changes in suicide risk suggest that acculturation and socioeconomic deprivation may account for a convergence of suicide risk between migrants and the host population over time. DECLARATION OF INTEREST: None. PMID: 31608849 [PubMed - as supplied by publisher]
DiscussionThe pattern of immune dysregulation in zoster patients is similar to that of astronauts during spaceflight who shed VZV DNA in their saliva. Because future deep space exploration missions will be of an unprecedented duration, prolonged immune depression and chronic viral reactivation threaten to manifest overt disease in exploration class astronauts.
Publication date: Available online 14 October 2019Source: Speech CommunicationAuthor(s): Brian Stasak, Julien Epps, Roland GoeckeAbstractIn the future, automatic speech-based analysis of mental health could become widely available to help augment conventional healthcare evaluation methods. For speech-based patient evaluations of this kind, protocol design is a key consideration. Read speech provides an advantage over other verbal modes (e.g. automatic, spontaneous) by providing a clinically stable and repeatable protocol. Further, text-dependent speech helps to reduce phonetic variability and delivers controllable linguist...
In conclusion, prior to mental health clinical practices, standardized patient simulation may help nursing students gain experience. PMID: 31609152 [PubMed - as supplied by publisher]