Factors Associated with Diagnosis and Treatment of Thyroid Microcarcinomas.

Factors Associated with Diagnosis and Treatment of Thyroid Microcarcinomas. J Clin Endocrinol Metab. 2019 Aug 15;: Authors: Esfandiari NH, Hughes DT, Reyes-Gastelum D, Ward KC, Hamilton AS, Haymart MR Abstract CONTEXT: Nearly one-third of all thyroid cancers are ≤ 1 cm. OBJECTIVE: Determine diagnostic pathways for microcarcinomas versus larger cancers. DESIGN/SETTING/PATIENT PARTICIPANTS: Patients from Georgia and Los Angeles Surveillance, Epidemiology, and End Results (SEER) registries with differentiated thyroid cancer diagnosed in 2014-2015 were surveyed (response rate 63%). Survey data were linked to SEER data on tumor and treatment characteristics. Multivariable logistic regression analysis was performed. MAIN OUTCOME MEASURES: method of nodule discovery; reason for thyroid surgery. RESULTS: Of patients who underwent surgery, 975 (38.2%) had cancers ≤ 1 cm, and 1588 (61.8%) were> 1 cm. The reported method of nodule discovery differed significantly between patients with cancer ≤ 1 cm versus> 1 cm (p
Source: The Journal of Clinical Endocrinology and Metabolism - Category: Endocrinology Authors: Tags: J Clin Endocrinol Metab Source Type: research

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Researchers from China have developed a radiomics model capable of identifying...Read more on AuntMinnie.comRelated Reading: Deep learning comparable to rads for thyroid management AI can improve reproducibility of radiomics in CT AI can optimize risk stratification of thyroid nodules Ultrasound CADx software can stratify thyroid nodules CAD helps less-experienced rads diagnose thyroid cancer
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Purpose of review Compared with adults, there is a two-fold to three-fold increased risk of malignancy for a pediatric patient undergoing evaluation of a thyroid nodule. In 2015, the American Thyroid Association published guidelines on the evaluation and management of pediatric patients with thyroid nodules and differentiated thyroid cancer. The goal of this clinical update is to review recent additions to the literature and propose opportunities how to best incorporate these findings into clinical practice. Recent findings Recent additions to the literature include assessment of ultrasound-based scoring systems to im...
Source: Current Opinion in Endocrinology, Diabetes and Obesity - Category: Endocrinology Tags: THYROID: Edited by Angela M. Leung Source Type: research
CONCLUSION: More than 50% of low-risk PTMC are on AS in Japan. However, the indication and recommendation for AS vary significantly between institutions. To improve the implementation of this management modality, physicians and patients should be further educated, and the socio-medical environment should be improved. PMID: 31441377 [PubMed - as supplied by publisher]
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research
ConclusionsSubclassification of AUS/FLUS into three groups based on cytopathologic findings alone not only improved the triage of patients for subsequent clinical management but also effectively stratified the risk of malignancy.
Source: Journal of the American Society of Cytopathology - Category: Cytology Source Type: research
Authors: Li J, Wang Q, Wang L, Wang J, Wang D, Xin Z, Liu Y, Zhao Q Abstract Diagnostic value of fine-needle aspiration (FNA) combined with ultrasound for thyroid cancer was evaluated. A retrospective analysis was performed on the preoperative FNA and ultrasound data of 165 thyroid nodule patients, were divided into group A (≤1 cm group) and group B (>1 cm group) based on the maximum diameter line of the thyroid nodule. The sensitivity, specificity, accuracy, positive predictive value and negative predictive value of FNA, ultrasound and FNA combined with ultrasound in the diagnosis of thyroid cancer were anal...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
DIFFERENTIATED THYROID CANCER IN PEDIATRIC POPULATION (≤18 YEARS): POSTOPERATIVE TREATMENT WITH RADIOACTIVE IODINE (I-131). Acta Clin Croat. 2019 Mar;58(1):119-127 Authors: Prpić M, Franceschi M, Jukić T, Kust D, Dabelić N, Varjačić T, Lucijanić M, Bolanča A, Kusić Z Abstract The aim is to present data on the treatment and follow-up in a cohort of patients with pediatric thyroid cancer who underwent total thyroidectomy and received postoperative radioactive iodine (I-131) therapy. The study was conducted in a tertiary high-volume thyroid center, in pediatric patients with differentiated thyr...
Source: Acta Clinica Croatica - Category: General Medicine Tags: Acta Clin Croat Source Type: research
Abstract BACKGROUND: About 10% of thyroid cancers are medullary thyroid carcinoma (MTC) and can occur sporadically, familially and in the context of type II multiple endocrine neoplasia (MEN). Imaging plays a pivotal role in screening family members and in diagnosis. DIAGNOSTIC METHODS: Diagnosis is based on ultrasound (US), thyroid scintigraphy, serum calcitonin and carcinoembryonic antigen (CEA) as well as fine needle biopsy. High-resolution US is the most important imaging method for locoregional staging, combined with computed tomography (CT) of the mediastinum. Positron emission tomography (PET...
Source: Der Radiologe - Category: Radiology Authors: Tags: Radiologe Source Type: research
ConclusionsRFA was effective in patients with PTMC+CLT, and its therapeutic efficacy and safety were similar to those in patients with PTMC without CLT.
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
Thyroid nodules are quite commonly found in the general population; however, the incidence of thyroid cancer can be found in 5-15% of the general population (depending on age, gender, and other risk factors). Ultrasound is the primary diagnostic modality used to diagnose and characterize thyroid nodules, and due to the ready availability and economic efficiency of imaging, thyroid nodules are being diagnosed (often incidentally) at higher rates. Conventional ultrasound parameters have been utilized to predict benignity or risk of malignancy in nodules and facilitate the decision making for intervention; however, no imaging...
Source: Journal of Medical Imaging and Radiation Sciences - Category: Radiology Authors: Source Type: research
CONCLUSIONS: In this study, we generated a new mouse model of multi-step thyroid cancer dedifferentiation with evidence of progression from PTC to PDTC and ATC. Further, PDTC in these mice showed two distinct histologic appearances correlated with levels of expression of thyroid differentiation and iodine metabolism genes, suggesting a possibility of existence of two PDTC types with different functional characteristics and potential implication for therapeutic approaches to these tumors. PMID: 31298630 [PubMed - as supplied by publisher]
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research
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