Tumours of the male genital tract

This article discusses pathological features of tumours of the male genital tract. Carcinoma of the prostate is common and represents an increasing burden to the NHS in terms of management and treatment. We focus on recent changes to grading and discuss issues around pathological diagnosis. Tumours of the testes represent the greatest success story of cancer treatment over the past several decades. We review the pathological features of the commonest tumours focusing on prognostic features. Carcinoma of the penis is rare but appears to be increasing in incidence. It requires more awareness amongst the public and general practitioners to prevent presentation at an advanced stage. We focus on pre-invasive lesions and on the pathological staging of this disease.
Source: Surgery (Oxford) - Category: Surgery Source Type: research

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Conclusions In our study, the previously developed nomogram that was applied to our population had low accuracy and low precision for correctly identifying patients with PC who have positive ILNs.
Source: International Braz J Urol - Category: Urology & Nephrology Source Type: research
Conclusions In our study, the previously developed nomogram that was applied to our population had low accuracy and low precision for correctly identifying patients with PC who have positive ILNs.
Source: International Braz J Urol - Category: Urology & Nephrology Source Type: research
Doctors at the Koto Hospital in Tokyo, Japan, had to surgically remove the elastic band from the man's penis and then take off part of the flesh which had a carcinoma skin cancer growing on it.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Purpose of review Penile squamous cell carcinoma (PSCC) remains a challenging malignancy to treat and there is an urgent need of significant improvements at all levels of medical care. In the current review, we summarized the significant obstacles encountered during management of PSCC and discussed the clinical relevance of novel findings and their potential to address these obstacles. Recent findings The recent genetic and immunological advances suggest that patients with PSCC can benefit from available targeted therapy and immunotherapy options. Moreover, evidence has accumulated over time suggesting that majority o...
Source: Current Opinion in Supportive and Palliative Care - Category: Palliative Care Tags: RENAL AND UROLOGICAL PROBLEMS: Edited by Fred Saad Source Type: research
CONCLUSIONS.—: Understanding of the molecular oncology of genitourinary neoplasms is rapidly advancing, and the pathologist must be aware of the practical implications of molecular testing. While many genomic abnormalities are not yet clinically relevant, there is an increasing library of ancillary tests that may guide diagnosis, prognosis, and/or treatment of many neoplasms. Recurrent genomic abnormalities have been identified in many types of renal cell carcinoma, and some types of renal cell carcinoma are specifically defined by the molecular abnormality. Two major routes of developing urothelial carcinoma have be...
Source: Archives of Pathology and Laboratory Medicine - Category: Laboratory Medicine Authors: Tags: Arch Pathol Lab Med Source Type: research
Authors: Choo R, Nehra A, Zattoni F, Pagliaro LC, Karnes RJ Abstract PURPOSE: To evaluate whether there is any benefit in adding postoperative adjuvant concurrent radiotherapy and chemotherapy (RT-CHT) for penile cancer with regional lymph node metastasis (RLNM). MATERIALS AND METHODS: A single institution, retrospective study was conducted for a total of 23 patients with RLNM from penile squamous cell carcinoma. All underwent a definitive surgical intervention for both primary tumor and RLNM. Of these, 11 patients received adjuvant concurrent RT and CHT within 3 months after surgery (RT-CHT Group), while 12 pa...
Source: Minerva Urologica e Nefrologica - Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research
AbstractPurposeTo test the conditional survival that examined the effect of event-free survival on cancer-specific mortality after primary tumour excision (PTE) in patients with squamous cell carcinoma of the penis (SCCP).Materials and methodsWithin the SEER database (1998 –2015), 2282 stage I–III SCCP patients were identified. Conditional survival estimates were used to calculate cancer-specific mortality (CSM) after event-free survival intervals of 1, 2, 3, and 5 years. Multivariable Cox regression models predicted CSM according to event-free survival.ResultsAfter PTE, 5-year CSM-free rate was 78.0% and ...
Source: World Journal of Urology - Category: Urology & Nephrology Source Type: research
Abstract INTRODUCTION: We analyzed adherence rates to contemporary guidelines regarding inguinal lymph node dissection (ILND) for squamous cell carcinoma of the penis, as well as ILND association with cancer specific mortality (CSM), and complication rates. MATERIALS AND METHODS: Within the Surveillance, Epidemiology, and End Results and the National Inpatient Sample databases, 943 and 317 nonmetastatic penile cancer patients (1998-2015) were respectively identified. Multivariable analyses focused on ILND rates, CSM, and complication rates. Inverse probability of treatment weighting adjustment was used in CSM...
Source: Urologic Oncology - Category: Urology & Nephrology Authors: Tags: Urol Oncol Source Type: research
AbstractPenile squamous cell carcinoma is a rare malignancy with various distinct histological subtypes, each with distinct appearances, histotypic specific associations with human papillomavirus (HPV) and clinical behaviour. Despite a wealth of pathological knowledge, there still remains a limited understanding of the fundamental molecular drivers that govern penile carcinogenesis with their underlying prognostic and therapeutic importance. However, recent work has improved our fundamental understanding of the molecular pathogenesis of penile cancer: commonly divided into the HPV-dependent and HPV-independent pathways. Th...
Source: Virchows Archiv - Category: Pathology Source Type: research
Chemotherapy may be a valuable treatment option as neoadjuvant treatment for locally advanced penile cancer according to some previous studies, but the rarity of the sample and the Lack of large-scale clinical...
Source: BMC Cancer - Category: Cancer & Oncology Authors: Tags: Research article Source Type: research
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