Prolactin, flupenthixol decanoate and first episode schizophrenia – clinical and laboratory correlates

In this study treatment with flupenthixol decanoate was associated with relatively low levels of hyperprolactinemia, likely owing to flupenthixol’s relatively atypical mode of action, as well as to the low doses u sed in our study. We found an inverse correlation between total PANSS scores and prolactin levels, which could support the suggested theory of prolactin having antipsychotic properties. Our study confirms the importance of gender on the prolactin raising effects of antipsychotic treatment.
Source: Metabolic Brain Disease - Category: Neurology Source Type: research