Keratin defects trigger the itch-inducing cytokine thymic stromal lymphopoietin via Areg-Egfr signaling

Loss of the keratin cytoskeleton results in upregulation of the pro-inflammatory cytokine Tslp via autocrine Areg-Egfr-Erk1/2 signaling. The Areg-Egfr axis represents a therapeutical target to moderate Tslp, inflammation and itch in EBS.

Source: Journal of Allergy and Clinical Immunology - August 15, 2019 Category: Allergy & Immunology Authors: Andrea Scheffschick, Dimitra Kiritsi, Thomas M. Magin Source Type: research