Options of immunotherapeutic treatments for children with asthma.

This article will discuss the available evidence on allergen immunotherapy and biologic drugs in pediatric asthma treatment. Expert opinion: Previously published studies demonstrated a good efficacy and safety profile of Allergen Immunotherapy in patients with mild-moderate asthma and sensitization to one main allergen. New understanding of mechanisms underlying severe asthma inflammation has allowed the identifications of specific biomarkers guiding the clinician in the choice of patient specific drug. Among the suggested immunotherapeutic options, omalizumab (blocking IgE) remains the first choice for atopic "early onset" asthma in patients aged over 6 years. Instead, mepolizumab (blocking the IL5 ligand) should be considered for "eosinophilic" asthma. Other biologic drugs are under consideration but data on the pediatric population are still lacking. PMID: 31414917 [PubMed - as supplied by publisher]
Source: Expert Review of Respiratory Medicine - Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research

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ConclusionThe trial demonstrated a favorable safety profile of the SQ HDM SLIT-tablet in Japanese adult patients with AA. The treatment appeared to be efficacious in patients requiring rescue medication (i.e., SABA) at baseline in the efficacy assessment using asthma exacerbation during ICS reduction (JapicCTI number 121847).
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
Authors: Klein M, Magnan A, Bouchaud G Abstract Severe asthma required high dose of corticosteroids combined with biotherapies to control more or less asthma symptoms and lead to the decrease of patients' quality of life on long term. Recent studies show that hypoallergenic peptides derived from allergen can prevent airway hyperresponsiveness, decrease Th2 response and also allergen-specific IgE in mouse models of allergic asthma. Even if some peptides mechanisms remain unknown, their fast efficacy with low doses of allergens make peptide immunotherapy a new promising approach in allergic asthma. PMID: 31006580...
Source: Revue des Maladies Respiratoires - Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research
Skin prick/puncture testing (SPT) is currently considered the “gold standard” method for epicutaneous allergy testing. There are multiple advantages of SPT compared to in vitro testing. It is less expensive, less invasive, and provides faster, highly specific results, and a better correlation with inhalant allergy symptoms1. However, there are noted disadv antages to the SPT method, largely based on variability factors. These include controllable variables, such as patient medications (antihistamines, psychotropic agents, high dose oral corticosteroids, and immunotherapy), the device used for the SPT, and the t...
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Letters Source Type: research
Purpose of review Severe asthmatics, despite the chronic use of high inhaled corticosteroids (ICS) doses and frequent intake of systemic corticosteroids, remains clinically and/or functionally uncontrolled. These patients are also often affected by rhinitis or chronic rhinosinusitis requiring frequent use of intranasal corticosteroids. Therefore, severe asthmatics are exposed to an overload of corticosteroids that is frequently associated with relevant and costly adverse events. This clinical problem and the strategies to overcome it are here summarized. Recent findings Different therapeutic options may help in reduci...
Source: Current Opinion in Allergy and Clinical Immunology - Category: Allergy & Immunology Tags: MECHANISMS OF ALLERGY AND ADULT ASTHMA: Edited by J. Andrew Grant and Enrico Heffler Source Type: research
Discussion: As in other studies, omalizumab has shown favourable clinical benefits in patients with moderate to severe persistent allergic asthma, stabilizing lung function and maintaining diseases control with a good safety profile.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Allergy and immunology Source Type: research
We report atopic dermatitis treated successfully with allergen immunotherapy.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: M503 Source Type: research
AbstractPurpose of ReviewThis review analyzes the growing evidence regarding the standardized quality house dust mite (SQ-HDM) sublingual immunotherapy (SLIT) tablets as a valuable therapeutic option in asthma, as recently included in the treatment algorithm of the Global Initiative for Asthma (GINA) as an add-on treatment for adult patients with allergic asthma not well controlled with inhaled corticosteroids (ICS).Recent FindingsEvidence from well-designed randomized placebo-controlled clinical trials shows that the SQ-HDM SLIT tablet is effective vs. placebo in reducing both asthma symptoms and the need for ICS, as well...
Source: Current Treatment Options in Allergy - Category: Allergy & Immunology Source Type: research
AbstractPurpose of ReviewIn this article, we review the impact and the treatment of sleep disturbance caused by allergic rhinitis (AR) in adult and pediatric patients.Recent FindingsAlthough intranasal corticosteroids (INS) remain the mainstay treatments for AR-induced sleep disturbance, allergen immunotherapy (AIT) has been suggested to be effective in altering the course and progression of moderate-to-severe AR that is refractory to pharmacotherapy. MP-AzeFlu is a recently developed formulation containing azelastine, an intranasal antihistamine (INAH), and fluticasone propionate, an INS. MP-AzeFlu has been reported to ha...
Source: Current Treatment Options in Allergy - Category: Allergy & Immunology Source Type: research
AbstractPurpose of ReviewTo evaluate the impact of allergic rhinitis (AR) on the development of asthma and to update readers on recent literature suggesting that early treatment of allergic subjects with immunotherapy may prevent asthma onset.Recent FindingsAR is frequently associated with asthma, leading to the concept that these two conditions are different aspects of the same disease. There is increasing evidence that AR precedes the onset of asthmatic symptoms and current treatment strategies are beneficial in symptom control with no impact prevention. There is limited knowledge about the risk factors responsible for t...
Source: Current Allergy and Asthma Reports - Category: Allergy & Immunology Source Type: research
Conclusion: Fractional exhaled NO measurement can be used as a quick and reliable diagnostic method in patients presenting with chronic cough due to its high positive predictive value, its practical nature, the fact that it is a noninvasive method and that it does not require the use of medication.
Source: Nigerian Journal of Clinical Practice - Category: Rural Health Authors: Source Type: research
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