Aspects of cAMP Signaling in Epileptogenesis and Seizures and Its Potential as Drug Target.

Aspects of cAMP Signaling in Epileptogenesis and Seizures and Its Potential as Drug Target. Neurochem Res. 2019 Aug 14;: Authors: Mertz C, Krarup S, Jensen CD, Lindholm SEH, Kjær C, Pinborg LH, Bak LK Abstract Epilepsy is one of the most common chronic neurological conditions. Today, close to 30 different medications to prevent epileptic seizures are in use; yet, far from all patients become seizure free upon medical treatment. Thus, there is a need for new pharmacological approaches including novel drug targets for the management of epilepsy. Despite the fact that a role for cAMP signaling in epileptogenesis and seizures was first suggested some four decades ago, none of the current medications target the cAMP signaling system. The reasons for this are probably many including limited knowledge of the underlying biology and pathology as well as difficulties in designing selective drugs for the different components of the cAMP signaling system. This review explores selected aspects of cAMP signaling in the context of epileptogenesis and seizures including cAMP response element binding (CREB)-mediated transcriptional regulation. We discuss the therapeutic potential of targeting cAMP signaling in epilepsy and point to an increased knowledge of the A-kinase anchoring protein-based signaling hubs as being of seminal importance for future drug discovery within the field. Further, in terms of targeting CREB, we argue that targeting upstream cAMP signals m...
Source: Neurochemical Research - Category: Neuroscience Authors: Tags: Neurochem Res Source Type: research

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Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research
Vagus nerve stimulation for refractory epilepsy may induce laryngeal side effects such as dysphonia and dysphagia. Careful tuning of the stimulation parameters and collaboration between epileptologists and otolaryngologists can help significantly reduce side effects. AbstractVagus nerve stimulation for refractory epilepsy may induce laryngeal side effects such as dysphonia and dysphagia. Careful tuning of the stimulation parameters and collaboration between epileptologists and otolaryngologists can help significantly reduce side effects.
Source: Clinical Case Reports - Category: General Medicine Authors: Tags: CASE REPORT Source Type: research
We report a series of patients who underwent simultaneous tilt table testing with EEG. Diagnostic benefits are not exclusively the verification of EEG correlates secondary to clinical and cardiovascular changes during syncope, but also confirmation of nonphysiological events, including psychogenic nonepileptic seizures and psychogenic pseudosyncope. Fifty tilt table studies were combined with EEG over a six-year period. Seven studies (14%) captured episodes of behavioral unresponsiveness with normal EEG and EKG patterns, diagnostic of psychogenic pseudosyncope. Whereas psychogenic nonepileptic events are well established i...
Source: The Neurodiagnostic Journal - Category: Neurology Tags: Neurodiagn J Source Type: research
Authors: Akiyama T, Saigusa D, Hyodo Y, Umeda K, Saijo R, Koshiba S, Kobayashi K Abstract To characterize metabolic profiles within the central nervous system in epilepsy, we performed gas chromatography-tandem mass spectrometry (GC-MS/MS)-based metabolome analysis of the cerebrospinal fluid (CSF) in pediatric patients with and without epilepsy. The CSF samples obtained from 64 patients were analyzed by GC-MS/MS. Multivariate analyses were performed for two age groups, 0-5 years of age and 6-17 years of age, to elucidate the effects of epilepsy and antiepileptic drugs on the metabolites. In patients aged 0-5 years ...
Source: Acta Medica Okayama - Category: General Medicine Tags: Acta Med Okayama Source Type: research
Conditions:   Hyperhomocysteinemia, Thrombotic, Cbs-Related;   Ischemic Stroke;   Epilepsy Intervention:   Genetic: Methylenetetrahydrofolate reductase (MTHFR) deficiency Sponsor:   Istanbul Medeniyet University Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
The NINDS invites investigators and individuals interested in finding cures for the epilepsies to convene and participate in a forum and discussion of the progress made in understanding the mechanisms of the epilepsies, as well as the inroads made towards potential cures. A main outcome and priority of the meeting will be the evaluation and updating of the Epilepsy Research Benchmarks.For more information go tohttp://www.cvent.com/events/curing-the-epilepsies-2020-setting-research-priorities/event-summary-74ba3ba9a2994347829128974234f3aAir date: 4/15/2020 8:30:00 AM
Source: Videocast - All Events - Category: General Medicine Tags: Upcoming Events Source Type: video
The NINDS invites investigators and individuals interested in finding cures for the epilepsies to convene and participate in a forum and discussion of the progress made in understanding the mechanisms of the epilepsies, as well as the inroads made towards potential cures. A main outcome and priority of the meeting will be the evaluation and updating of the Epilepsy Research Benchmarks.For more information go tohttp://www.cvent.com/events/curing-the-epilepsies-2020-setting-research-priorities/event-summary-74ba3ba9a2994347829128974234f3aAir date: 4/13/2020 8:00:00 AM
Source: Videocast - All Events - Category: General Medicine Tags: Upcoming Events Source Type: video
The NINDS invites investigators and individuals interested in finding cures for the epilepsies to convene and participate in a forum and discussion of the progress made in understanding the mechanisms of the epilepsies, as well as the inroads made towards potential cures. A main outcome and priority of the meeting will be the evaluation and updating of the Epilepsy Research Benchmarks.For more information go tohttp://www.cvent.com/events/curing-the-epilepsies-2020-setting-research-priorities/event-summary-74ba3ba9a2994347829128974234f3aAir date: 4/14/2020 8:30:00 AM
Source: Videocast - All Events - Category: General Medicine Tags: Upcoming Events Source Type: video
CONCLUSIONS: DBS in epilepsy is still under investigation, with class I evidence for DBS of the anterior nucleus of the thalamus. The rest of the targets have yielded variable results that must be confirmed with randomised designs in larger series. PMID: 32100279 [PubMed - in process]
Source: Revista de Neurologia - Category: Neurology Authors: Tags: Rev Neurol Source Type: research
CONCLUSIONS: Given the high prevalence of sleep apnoea-hypopnoea syndrome in patients with refractory epilepsy, implantation of VNS should be ideally preceded by an assessment of the breathing during sleep. Furthermore, sleep-disordered breathing should be considered as a rare complication of VNS, and sleep apnoea should be investigated alongside data regarding VNS firing. PMID: 32100278 [PubMed - in process]
Source: Revista de Neurologia - Category: Neurology Authors: Tags: Rev Neurol Source Type: research
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