Optic Neuritis In the Era of Biomarkers

The Optic Neuritis Treatment Trial (ONTT), a landmark study completed in 1991, stratified the risk of multiple sclerosis (MS) in patients with optic neuritis. Since that time, unique biomarkers for optic neuritis have been found. The antibody against aquaporin-4, (AQP4)-immunoglobulin G (IgG), discovered in 2004, was found to be both the pathologic cause and a reliable biomarker for neuromyelitis optica spectrum disorders (NMOSD). This finding enabled an expanded definition of the phenotype of NMOSD and improved treatment of the disease.
Source: Survey of Ophthalmology - Category: Opthalmology Authors: Tags: Major review Source Type: research