Comparing the efficacy of Pulsed Dye Laser, Q-Switched Nd-YAG, CO2, and combined CO2 and Q-Switched Nd-YAG Lasers for the Treatment of Cutaneous Macular Amyloidosis.

CONCLUSION: the CO2 laser is seems to be the most effective laser treatment of CMA. PMID: 31415215 [PubMed - as supplied by publisher]
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research

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We report a 58-year-old Japanese woman who presented with nephrotic syndrome. Steroid therapy and cyclosporine A administration were initiated, but hematological remission and renal response were not achieved. Renal biopsy revealed amyloid deposits in the mesangial region and the small arteries. Proteomic analysis based on laser microdissection and mass spectrometry showed that the amyloid deposits were composed of the constant region of the lambda light chain. She received vincristine, adriamycin, and dexamethasone therapy followed by high-dose melphalan and autologous stem cell transplantation, resulting in hematological...
Source: CEN Case Reports - Category: Urology & Nephrology Source Type: research
Publication date: Available online 12 September 2019Source: Journal de Mycologie MédicaleAuthor(s): Dharmesh Patel, Ritesh Agarwal, Sahajal Dhooria, Umapati Hedge, Hardik Patel, Inderpaul Singh SehgalAbstractSecondary amyloidosis results from the deposition of abnormally folded proteins in body organs due to chronic inflammatory disorders. Kidneys are the most commonly affected organ and manifest as nephrotic syndrome with or without renal failure. Chronic pulmonary aspergillosis (CPA) is a chronic infection of lung parenchyma affecting those with an underlying structural lung disease. Herein, we present a case of C...
Source: Journal of Medical Mycology - Category: Biology Source Type: research
AbstractPurpose of ReviewThe review ’s main focus centers on the genetics of hereditary cardiac amyloidosis, highlighting the opportunities and challenges posed by the widespread availability of genetic screening and diagnostic cardiac imaging.Recent FindingsAdvancements in cardiac imaging, heightened awareness of the ATTR amyloidosis diagnosis, and greater access to genetic testing have all led to an increased appreciation of the prevalence of ATTR cardiac amyloidosis. Elucidation of the TTR molecular structure and effect of mutations on TTR function have allowed for novel TTR therapy development leading to clinical...
Source: Current Heart Failure Reports - Category: Cardiology Source Type: research
ConclusionOur findings reveal that ATTR p.A97S is a cardiomyopathy as well as a polyneuropathic syndrome. Routine use of more contemporary echocardiographic techniques are recommended to identify cardiac amyloidosis and provide prognostic information.
Source: Journal of the Formosan Medical Association - Category: General Medicine Source Type: research
AbstractBackgroundThe aim of our study was to investigate outcomes of patients with ATTR CA and implantable devices with respect to left ventricular ejection fraction (LVEF), mitral regurgitation (MR), New York Heart Association (NYHA) functional class and mortality.MethodsThis was a retrospective observational cohort study of 78 patients with ATTR CA and implantable devices. During a mean follow ‐up of 42 months we investigated the impact of RV pacing burden and BiV pacing on LVEF, MR severity, NYHA functional class and mortality.ResultsWorsening MR occurred in 11% of patients with a RV pacing % 40% (p=0.002). Similarly...
Source: Journal of Cardiovascular Electrophysiology - Category: Cardiology Authors: Tags: ORIGINAL ‐ CLINICAL Source Type: research
CONCLUSION: Our findings reveal that ATTR p.A97S is a cardiomyopathy as well as a polyneuropathic syndrome. Routine use of more contemporary echocardiographic techniques are recommended to identify cardiac amyloidosis and provide prognostic information. PMID: 31521469 [PubMed - as supplied by publisher]
Source: J Formos Med Assoc - Category: General Medicine Authors: Tags: J Formos Med Assoc Source Type: research
AbstractBackgroundWe evaluated the diagnostic performance of18F-NaF PET/MRI in patients with suspected cardiac amyloidosis (CA).MethodsTwenty-seven consecutive patients underwent myocardial PET 1 hour after injection of 4 MBq/kg18F-NaF with simultaneous MRI including cine-MRI, T1 and T2 mapping, first-pass and late gadolinium enhancement (LGE).18F-NaF uptake was measured visually and semi-quantitatively by calculating myocardium-to-blood pool (M/B) ratios. CA was confirmed histologically.ResultsTransthyretin (TTR)-CA was diagnosed in 16 patients, light-chain (AL)-CA in 7, and no-CA in 4. Visual interpretation of18F-NaF ima...
Source: Journal of Nuclear Cardiology - Category: Nuclear Medicine Source Type: research
Authors: Huang WH, Hu CC, Yen TH, Hsu CW, Weng CH Abstract Introduction: Carpal tunnel syndrome (CTS) is a severe complication observed in long-term maintenance hemodialysis (MHD) patients. The most common cause of CTS is dialysis-related β2-microglobulin amyloidosis, which is associated with inflammation and oxidative stress in dialysis patients. Patients on MHD have higher blood lead levels (BLLs) than the general population. Lead (Pb) exposure in chronic dialysis patients has been noted to induce oxidative stress and inflammation. Therefore, lead-related inflammation and oxidative stress might contribute to...
Source: Renal Failure - Category: Urology & Nephrology Tags: Ren Fail Source Type: research
We report a case of a 39-year-old male with autosomal dominant dystrophic EB, presenting with bilateral leg swelling of one-week duration. There was no other significant past medical history. The physical examination was remarkable for scars and erosions over all body areas, with all extremities with blisters and ulcers covered, absent finger and toenails and bilateral lower extremity edema. Serum creatinine was 0.9 mg/dL, albumin 1.3 g/dL and urine protein excretion 3.7 g/24 h. Viral markers (hepatitis-B, C, and HIV), complement c3 and c4 levels and auto-immune antibody profile all remained neg...
Source: Renal Failure - Category: Urology & Nephrology Tags: Ren Fail Source Type: research
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Source: Amyloid: The Journal of Protein Folding Disorders - Category: Biochemistry Authors: Source Type: research
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