Strategies of Targeting Pathological Stroma for Enhanced Antitumor Therapies

Publication date: Available online 15 August 2019Source: Pharmacological ResearchAuthor(s): Yun Zhu, Fangying Yu, Yanan Tan, Hong Yuan, Fuqiang HuAbstractCancer associated fibroblasts (CAFs) and the derived stromal components constitute specific pathological stroma in desmoplastic tumors, which not only hinder the distribution of drugs/nano-agents in tumors but also reduce the sensibility of tumor cells to standard therapeutics. Consequently, pathological stroma has gradually been termed potential target for antitumor therapy. However, opposite outcomes have been observed to occur with the same strategy in different tumor models and no general principles have been adopted due to the heterogeneity and adaptivity of dynamic stroma, in which case diversified strategies for antitumor therapies are urgent. In this review, we summarize the origins and characterizations of pathological stroma and describe their critical influence on tumor’s responsiveness to oncotherapy. The design of combinational antitumor strategies and stroma targeting drug delivery systems (DDSs) are also discussed in detail. Collectively, the main purpose of this review is to improve our understanding of the roles of stroma in tumor progression and provide new insights for targeting pathological stroma.Graphical abstract
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research

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Authors: Ghossoub E, Minchin S, Hayreh D, Newman WJ Abstract Treatment with antipsychotics is a mainstay of trial competency restoration, particularly given that most defendants deemed incompetent to stand trial have psychotic illnesses. We explored the association between competency restoration and antipsychotic type in a retrospective sample of defendants diagnosed with psychotic disorders and deemed incompetent to stand trial. Using regression models, we calculated the odds ratio of being competent to stand trial, adjusting for relevant confounders. We found that the use of long-acting injectable antipsychotics ...
Source: Journal of the American Academy of Psychiatry and the Law - Category: Medical Law Tags: J Am Acad Psychiatry Law Source Type: research
This article reviews the approaches to and limitations of psychiatric assessment and contrasts this with the promise of these new technologies. It then discusses the ethics concerns associated with these technologies and explores their potential relevance to criminal forensic psychiatry and the broader implications they carry for health and criminal justice policy. PMID: 31533994 [PubMed - as supplied by publisher]
Source: Journal of the American Academy of Psychiatry and the Law - Category: Medical Law Tags: J Am Acad Psychiatry Law Source Type: research
This article reviews the history of the U.S. Supreme Court's rulings on intellectual disability in capital cases, highlighting the difficulty states have had in devising a workable definition that meets constitutional standards. The Court's decisions in Penry v. Lynaugh (1989), Atkins v. Virginia (2002), and Hall v. Florida (2014) are briefly summarized. Next, the Texas Court of Criminal Appeals' ruling in Ex parte Briseno (2004) is discussed as a prelude to the Supreme Court's decision in Moore v. Texas I (2017). On remand, the Texas Court of Criminal Appeals interpreted the Supreme Court's Moore I ruling in a manner that...
Source: Journal of the American Academy of Psychiatry and the Law - Category: Medical Law Tags: J Am Acad Psychiatry Law Source Type: research
This article reviews implications of cannabis use for defendants' eligibility and participation in problem-solving courts, with a focus on adult drug courts and mental health courts. This article also examines a range of policies, such as abstinence-based, tolerance-based, and adaptive approaches, that problem-solving courts may consider implementing. Further research is needed to characterize existing problem-solving court policies toward cannabis use and to develop evidence-based practices that courts may follow. PMID: 31533992 [PubMed - as supplied by publisher]
Source: Journal of the American Academy of Psychiatry and the Law - Category: Medical Law Tags: J Am Acad Psychiatry Law Source Type: research
Walmart said Friday that it will stop selling electronic cigarettes at its namesake stores and Sam's Clubs following a string of mysterious illnesses and deaths related to vaping.
Source: Arkansas Business - Health Care - Category: American Health Source Type: news
In this study, we investigate the time-frequency analysis (TFA) method, together with the wavelet filtering of the Daubechies method and the relative power spectrum analysis of the Fourier Welch method to extract and analyse the TRBA caused by the 2008 Wenchuan Ms 8.0 earthquake and the TRA of the 2013 Minxian-Zhangxian Ms 6.6 earthquake using data concerning the brightness temperature of a black body (TBB) from the Fengyun-2 series of geostationary meteorological satellites developed by China. The result showed that this method can effectively extract and analyse the TRBA caused by the Wenchuan earthquake and the TRA of t...
Source: Advances in Space Research - Category: Science Source Type: research
Publication date: Available online 19 September 2019Source: Advances in Space ResearchAuthor(s): E.L. Tang, Z.Q. Liang, L.Wang, Y.F. HanAbstractIn view of the objective reality that it takes a long time for debris to locate the impact point when debris impacts the spacecraft bulkhead, timely and accurate determination of the location of the impact source is the premise and basis for damage repair, which is of great significance to the safety of astronauts. In this paper, the experiments of 2A12 aluminium plate impacted by 2A12 aluminium projectile under different impact parameters have been performed by using the self-buil...
Source: Advances in Space Research - Category: Science Source Type: research
Conclusions: The abnormal location of FLT3 caused by different glycosylation status leads to the distinguishing signaling pathways. Targeting on FLT3 glycosylation may provide a new perspective for therapeutic strategies. Abbreviations: ABCG2: ATP-binding cassette transporter breast cancer resistance protein; ATF: activating transcription factor; AML: acute myeloid leukemia; CHOP: CCAAT-enhancer-binding protein homologous protein; 2-DG: 2-deoxy-D-glucose; EFS: event free survival; EPO: erythropoietin; EPOR: erythropoietin receptor; ERS: endoplasmic reticulum stress; FLT3: FMS-like tyrosine kinase 3; GPI: glycosylphosphatid...
Source: Hematology - Category: Hematology Tags: Hematology Source Type: research
Source: Journal of Computational and Theoretical Nanoscience - Category: Nanotechnology Authors: Tags: research-article Source Type: research
Source: Journal of Computational and Theoretical Nanoscience - Category: Nanotechnology Authors: Tags: research-article Source Type: research
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