Inhibitory effect of kaempferol on skin fibrosis in systemic sclerosis by the suppression of oxidative stress

Systemic sclerosis (SSc) is a connective tissue disorder characterized by the development of fibrosis in the skin and internal organs, as well as microvascular dysfunction [1,2]. Vasculopathy occurs at an early step of SSc. Almost all patients present Raynaud's phenomenon as an initial symptom, and frequently show other manifestations of vascular diseases, including ischemic digital ulcers, pulmonary arterial hypertension, and renal arterial involvement associated with malignant hypertension and renal failure.
Source: Journal of Dermatological Science - Category: Dermatology Authors: Source Type: research

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We describe the case of a patient with myelofibrosis (MF)-associated PH who developed left ventricular dysfunction after five years of treatment with the JAK 1/2 inhibitor, ruxolitinib. This is the first report with histopathological findings that demonstrate possible contradictory effects of a JAK 1/2 inhibitor: improvement of MF-associated PH and cardiotoxicity. PMID: 31534088 [PubMed - as supplied by publisher]
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
An EMA advisory panel recommended marketing authorization for netarsudil ophthalmic solution 0.02% for the treatment of adults with glaucoma or ocular hypertension.International Approvals
Source: Medscape FamilyMedicine Headlines - Category: Primary Care Tags: Ophthalmology News Alert Source Type: news
In this study of the National Trauma Data Bank Data set (2007–2009 and 2010–2016), these rates were reexamined and risk factors associated with these complications were assessed. Data quality is improved in the later data set; the incidence of deep venous thrombosis and pulmonary embolism was 0.28% and 0.21%, respectively, in the 2010–2016 data. Prophylaxis, male gender, treatment in a university hospital, open reduction, chronic obstructive pulmonary disease, and hypertension were notable significant risk factors for pulmonary embolism. For deep venous thrombosis, male gender, bleeding disorder, angina, ...
Source: The Journal of Foot and Ankle Surgery - Category: Orthopaedics Source Type: research
Authors: Dhont S, de Niel C, van Mieghem C PMID: 31536466 [PubMed - as supplied by publisher]
Source: Acta Cardiologica - Category: Cardiology Tags: Acta Cardiol Source Type: research
Conclusion: Renal allograft damage caused by BKVN involved T lymphocyte-, B lymphocyte- and mononuclear macrophage-mediated immune responses. Inflammatory cell infiltrations in the renal allograft were probably the driving force for BKVN progression. Additionally, eosinophils and neutrophils may be involved in the pathophysiological mechanism of BKVN. PMID: 31535918 [PubMed - in process]
Source: Renal Failure - Category: Urology & Nephrology Tags: Ren Fail Source Type: research
Conclusion: We identified the physicians' prescription patterns of antihypertensive drugs for treatment-naïve patients. The findings of this study can lead to a rational, evidence-based, and cost-effective improvement of prescription patterns in newly diagnosed hypertensive patients. PMID: 31534797 [PubMed]
Source: International Journal of Hypertension - Category: Cardiology Tags: Int J Hypertens Source Type: research
FRIDAY, Sept. 20, 2019 -- Kidney donation is associated with an increased risk for hypertension, according to a study published online Sept. 19 in the Clinical Journal of the American Society of Nephrology. Courtenay M. Holscher, M.D., from the...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
Authors: Chang Z, Zhang P, Zhang M, Jun F, Hu Z, Yang J, Wu Y, Zhou R Abstract Abnormal pulmonary arterial vascular smooth muscle cells (PASMCs) proliferation is critical pathological feature of pulmonary vascular remodeling that acts as driving force in the initiation and development of pulmonary arterial hypertension (PAH), ultimately leading to pulmonary hypertension. Aloperine is a main active alkaloid extracted from the traditional Chinese herbal Sophora alopecuroides and possesses outstanding antioxidation and anti-inflammatory effects. Our group found Aloperine has protective effects on monocroline-induced p...
Source: The Chinese Journal of Physiology - Category: Physiology Tags: Chin J Physiol Source Type: research
Conclusion: In healthy pregnancy, we reported CIMT was related to BMI and maternal age but not parity or gestational age. PMID: 31535936 [PubMed - as supplied by publisher]
Source: Hypertension in Pregnancy - Category: OBGYN Tags: Hypertens Pregnancy Source Type: research
This report has basically focused on scleroderma renal crisis (SRC), which is the most serious renal manifestation of SSc, characterized by renal failure and sudden onset of hypertension. A 44-year-old man was hospitalized with hypertension, headache, vertigo, nausea, rhinorrhea, reflux, dysphagia, dyspnea (Fc II), visual impairment, mechanical arthralgia, and edema (+3) accompanied by a rare skin lesion. Raynaud's phenomenon was also remarkable in fingers and toes. According to signs and symptoms, SSc diagnosed and the proper treatment was applied. It is of great importance that in the case of malignant hypertension in pa...
Source: Iranian Journal of Kidney Diseases - Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research
More News: Cancer & Oncology | Dermatology | Hypertension | Raynaud's Phenomenom | Renal Failure | Science | Scleroderma | Skin