TLR3 in Chronic Human Itch: A Keratinocyte-Associated Mechanism of  Peripheral Itch Sensitization

The acute itch-scratch reflex, considered a protective and evolutionarily conserved mechanism, can become dysfunctional in the setting of many chronic skin diseases, resulting in chronic itch (Mollanazar et  al., 2016; Steinhoff et al., 2018; Talwalkar et al., 2003). The resultant debilitating itch-scratch cycle can occur in inflammatory skin diseases; neurological diseases (Meng et al., 2018; Steinhoff et al., 2012); and systemic conditions such as cancer, diabetes, and renal or hepatic disorders (Matterne et al., 2011; Talwalkar et al., 2003).

Source: Journal of Investigative Dermatology - May 23, 2019 Category: Dermatology Authors: Attila G ábor Szöllősi, Ian McDonald, Imre Lőrinc Szabó, Jianghui Meng, Ellen van den Bogaard, Martin Steinhoff Tags: Letters to the Editor Source Type: research