Sudden cardiac death in patients with Myocarditis: Evaluation, risk stratification, and management

Publication date: Available online 15 August 2019Source: American Heart JournalAuthor(s): Fatima Ali-Ahmed, Frederik Dalgaard, Sana M. Al-KhatibAbstractMyocarditis is a major cause of sudden cardiac death (SCD) and dilated cardiomyopathy (DCM) in young adults. Cardiac magnetic resonance (CMR) is the established tool for the diagnosis of myocarditis, and late gadolinium enhancement (LGE) detected on CMR imaging is the strongest independent predictor of SCD, all-cause mortality, and cardiac mortality. Several other factors have been associated with SCD or cardiac transplantation including New York Heart Association functional class III/IV, reduced left ventricular ejection fraction (LVEF)
Source: American Heart Journal - Category: Cardiology Source Type: research

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Conclusions: We suggest some distinct molecular mechanisms for production of IL-1β in innate immune cells from patients with different clinical forms of Chagas disease. MMP-2 and MMP-9 gelatinases are associated with distinct disease outcomes and IL-1β production. Introduction Chagas disease, also known as American trypanosomiasis, is a neglected parasitic disease caused by the protozoan Trypanosoma cruzi (1), that affects millions of people in the world (2). During the acute phase, a diffuse and intense inflammation in the cardiomyocytes is observed, which is composed mainly of neutrophils, monocytes, and ...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Discussion Barth syndrome is characterized by a dilated cardiomyopathy, proximal skeletal muscle weakness, neutropenia and short stature that usually presents at birth or soon after. It is a rare X-linked recessive disease process caused by mutations in the TAZ gene. The TAZ gene codes for tafazzin which alters cardiolipin in mitochondria. Characteristic facies can be seen especially in infancy including a tall and broad forehead, prominent chin and full cheeks, larger ears, and deep-set eyes. Most patients present at birth or soon afterwards but some may not until later in life. Life expectancy is reduced with many childr...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
Authors: Schlitt A, Guha M, Noutsias M, Klein HH, Klein HU Abstract Assessment of a permanent risk of life-threatening ventricular arrhythmia in patients with severely reduced left ventricular ejection fraction (LVEF
Source: Herz - Category: Cardiology Tags: Herz Source Type: research
Publication date: Available online 10 February 2017 Source:The Lancet Author(s): Robert G Weintraub, Christopher Semsarian, Peter Macdonald Dilated cardiomyopathy is defined by the presence of left ventricular dilatation and contractile dysfunction. Genetic mutations involving genes that encode cytoskeletal, sarcomere, and nuclear envelope proteins, among others, account for up to 35% of cases. Acquired causes include myocarditis and exposure to alcohol, drugs and toxins, and metabolic and endocrine disturbances. The most common presenting symptoms relate to congestive heart failure, but can also include circulatory colla...
Source: The Lancet - Category: Journals (General) Source Type: research
Dilated cardiomyopathy is defined by the presence of left ventricular dilatation and contractile dysfunction. Genetic mutations involving genes that encode cytoskeletal, sarcomere, and nuclear envelope proteins, among others, account for up to 35% of cases. Acquired causes include myocarditis and exposure to alcohol, drugs and toxins, and metabolic and endocrine disturbances. The most common presenting symptoms relate to congestive heart failure, but can also include circulatory collapse, arrhythmias, and thromboembolic events.
Source: LANCET - Category: General Medicine Authors: Tags: Seminar Source Type: research
CONCLUSIONS: A non-invasive approach including clinical, laboratory and imaging evaluation is key for early CVD detection in SLE. PMID: 27687024 [PubMed - as supplied by publisher]
Source: Lupus - Category: Rheumatology Authors: Tags: Lupus Source Type: research
This review aims to give an update on the pathogenesis, clinical manifestations, and diagnosis of arrhythmogenic right ventricular cardiomyopathy (ARVC). Arrhythmogenic right ventricular cardiomyopathy is mainly an autosomal dominant inherited disease linked to mutations in genes encoding desmosomes or desmosome-related proteins. Classic symptoms include palpitations, cardiac syncope, and aborted cardiac arrest due to ventricular arrhythmias. Heart failure may develop in later stages. Diagnosis is based on the presence of major and minor criteria from the Task Force Criteria revised in 2010 (TFC 2010), which includes evalu...
Source: Europace - Category: Cardiology Authors: Tags: REVIEWS Source Type: research
Although the clinical spectrum of acute myocarditis varies from cardiogenic shock to asymptomatic electrocardiographic abnormalities during community viral outbreaks, its 3 most common clinical presentations are chest pain mimicking acute myocardial infarction, ventricular arrhythmias, and heart failure due to new-onset dilated cardiomyopathy (DCM) (1,2). Cardiac magnetic resonance (CMR) imaging has proven extremely valuable for assessment of clinically suspected myocarditis, by virtue of its ability to detect myocardial inflammation, myocardial edema, necrosis, and fibrosis (3). Several imaging sequences can acc...
Source: Journal of the American College of Cardiology - Category: Cardiology Source Type: research
Myocarditis is an inflammatory disease of the myocardium. Patients with myocarditis may present with acute coronary syndrome (ACS)-like symptoms, new-onset heart failure, life threatening arrhythmias and chronic heart failure [1,2]. Myocarditis may lead to sudden cardiac death or dilated cardiomyopathy. Endomyocardial biopsy is currently the gold standard for diagnosis of myocarditis. Cardiac magnetic resonance (CMR) imaging is a non-invasive and valuable clinical tool for diagnosing myocarditis.
Source: International Journal of Cardiology - Category: Cardiology Authors: Source Type: research
Idiopathic dilated cardiomyopathy (DCM) is the most common isoform of non-ischaemic cardiomyopathy and is characterised by dilatation of LV chamber and systolic dysfunction, which leads to progressive heart failure and a high risk for fatal arrhythmias. Although clinical manifestations are similar, DCM is not a single stage of a disease spectrum but may include several undetermined aetiologies, such as chronic myocarditis, tachycardia-induced cardiomyopathy, drug-induced cardiomyopathy, alcoholic cardiomyopathy, undiagnosed cardiac sarcoidosis and end-stage hypertrophic cardiomyopathy.1 Despite therapeutic advances in hear...
Source: Heart - Category: Cardiology Authors: Tags: Dilated cardiomyopathy, Hypertrophic cardiomyopathy, Drugs: cardiovascular system, Heart failure, Hypertension, Epidemiology Editorials Source Type: research
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